Evidence map›Paper›PMID 29088863›Full record

ArticleOncotarget2017

Whole-exome sequencing reveals genetic variants in ERC1 and KCNG4 associated with complete hydatidiform mole in Chinese Han women.

Yan Yu, Bingjian Lu, Weiguo Lu, Shuang Li, Xiuqin Li, Xinyu Wang, Xiaoyun Wan, Yaxia Chen, Suwen Feng, Yao Jia and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Molecular Basis of Hydatidiform Moles-A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Yan YuKey Laboratory of Women's Reproductive Health of Zhejiang Province, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Bingjian LuDepartment of Surgical Pathology, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Weiguo LuDepartment of Gynecologic Oncology, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Shuang LiDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xiuqin LiDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Xinyu WangDepartment of Gynecologic Oncology, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Xiaoyun WanDepartment of Gynecologic Oncology, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Yaxia ChenDepartment of Gynecologic Oncology, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Suwen FengDepartment of Gynecologic Oncology, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Yao JiaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ru YangDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Fangxu TangDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xiong LiDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Shulan ZhangDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Xinyan WangDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Heng WeiDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Zhilan PengDepartment of Obstetrics and Gynecology, West China Second Hospital of Sichuan University, Chengdu, Sichuan, China.
Lin LuDepartment of Obstetrics and Gynecology, West China Second Hospital of Sichuan University, Chengdu, Sichuan, China.
Huizhen ZhongDepartment of Obstetrics and Gynecology, Ningbo Women and Children's Hospital, Ningbo, Zhejiang, China.
Linjun ZhaoDepartment of Obstetrics and Gynecology, Ningbo Women and Children's Hospital, Ningbo, Zhejiang, China.
Zhangqian HuangDepartment of Obstetrics and Gynecology, Shaoxing Women and Children Hospital, Shaoxing, Zhejiang, China.
Lin LinZhejiang University Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Weihong ShenZhejiang University Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Yan LuDepartment of Gynecologic Oncology, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Zhu CaoKey Laboratory of Women's Reproductive Health of Zhejiang Province, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Jian ZouKey Laboratory of Women's Reproductive Health of Zhejiang Province, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Yuejiang MaKey Laboratory of Women's Reproductive Health of Zhejiang Province, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Xiaojing ChenKey Laboratory of Women's Reproductive Health of Zhejiang Province, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Qifang TianDepartment of Gynecologic Oncology, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Shiming LuDepartment of Clinical Laboratory, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Pengyuan LiuInstitute for Translational Medicine School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Ding MaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xing XieDepartment of Gynecologic Oncology, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Xiaodong ChengDepartment of Gynecologic Oncology, Women's Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complete hydatidiform mole (CHM) is a rare pregnancy-related disease with invasive potential. The genetics underlying the sporadic form of CHM have not been addressed previously, but maternal genetic variants may be involved in biparental CHM. We performed whole-exome sequencing of 51 patients with CHM and 47 healthy women to identify genetic variants associated with CHM. In addition, candidate variants were analyzed using single base extension and Matrix Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry in 199 CHM patients and 400 healthy controls. We validated candidate variants using Sanger sequencing in 250 cases and 652 controls, including 205 new controls. Two single nucleotide polymorphisms, c.G48C(p.Q16H) in

Indexed as

complete hydatidiform molegenomicspathogenesiswhole-exome sequencing

Identifiers

PMID29088863
PMCPMC5650418

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.