ArticleBrain : a journal of neurology2017
Preservation of hand movement representation in the sensorimotor areas of amputees.
Article in Brain : a journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Neural correlates of phantom motor execution: A functional neuroimaging systematic review and meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Pooled it
- Optimal Size of Electrocorticography Grids for Classification of Hand Movements.Neuroinformatics · 2026Article
- Optimal location for gesture decoding in the sensorimotor cortex and implications for brain-computer interface research.NeuroImage · 2026Article
- Article
- Stable cortical body maps before and after arm amputation.Nature neuroscience · 2025Article
- TMS-Based Neurofeedback Training of Mental Finger Individuation Induces Neuroplastic Changes in the Sensorimotor System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Decoding Single and Paired Phonemes Using 7T Functional MRI.Brain topography · 2024Article
- The speech neuroprosthesis.Nature reviews. Neuroscience · 2024Review
- Does Ipsilateral Remapping Following Hand Loss Impact Motor Control of the Intact Hand?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Enhancing prosthetic hand control: A synergistic multi-channel electroencephalogram.Wearable technologies · 2024Article
- Neural Correlates of Motor/Tactile Imagery and Tactile Sensation in a BCI paradigm: A High-Density EEG Source Imaging Study.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Against cortical reorganisation.eLife · 2023Article
- Direct speech reconstruction from sensorimotor brain activity with optimized deep learning models.Journal of neural engineering · 2023Article
- Article
- Morphology, Connectivity, and Encoding Features of Tactile and Motor Representations of the Fingers in the Human Precentral and Postcentral Gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cortical processing during robot and functional electrical stimulation.Frontiers in systems neuroscience · 2023Article
- Article
- Malleability of the cortical hand map following a finger nerve block.Science advances · 2022Article
- The Agonist-antagonist Myoneural Interface.Techniques in orthopaedics (Rockville, Md.) · 2021Article
- Distinct representation of ipsilateral hand movements in sensorimotor areas.The European journal of neuroscience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Denervation due to amputation is known to induce cortical reorganization in the sensorimotor cortex. Although there is evidence that reorganization does not lead to a complete loss of the representation of the phantom limb, it is unclear to what extent detailed, finger-specific activation patterns are preserved in motor cortex, an issue that is also relevant for development of brain-computer interface solutions for paralysed people. We applied machine learning to obtain a quantitative measure for the functional organization within the motor and adjacent cortices in amputees, using high resolution functional MRI and attempted hand gestures. Subjects with above-elbow arm amputation (n = 8) and non-amputated controls (n = 9) made several gestures with either their right or left hand. Amputees attempted to make gestures with their amputated hand. Images were acquired using 7 T functional MRI. The sensorimotor cortex was divided into four regions, and activity patterns were classified in individual subjects using a support vector machine. Classification scores were significantly above chance for all subjects and all hands, and were highly similar between amputees and controls in most regions. Decodability of phantom movements from primary motor cortex reached the levels of right hand movements in controls. Attempted movements were successfully decoded from primary sensory cortex in amputees, albeit lower than in controls but well above chance level despite absence of somatosensory feedback. There was no significant correlation between decodability and years since amputation, or age. The ability to decode attempted gestures demonstrates that the detailed hand representation is preserved in motor cortex and adjacent regions after denervation. This encourages targeting sensorimotor activity patterns for development of brain-computer interfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.