ArticlePloS one2017
Melanosis coli: Harmless pigmentation? A case-control retrospective study of 657 cases.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Colorectal neoplasms in melanosis coli: a survey in Japan and a worldwide meta-analysis.International journal of colorectal disease · 2021Pooled it
- Role of gut microbiota in melanosis coli: from anthraquinone biotransformation to mucosal homeostasis dysbiosis.Frontiers in pharmacology · 2026Review
- Melanosis Ilei Secondary to Chronic Iron Supplementation.European journal of case reports in internal medicine · 2026Article
- Colonoscopic Resolution of Melanosis Coli After Cessation of Senna Laxative Use.International medical case reports journal · 2024Article
- Melanosis of the urinary bladder.Annals of the Royal College of Surgeons of England · 2023Article
- Melanosis coli: a contrast effect or an oncogenic effect? A large-scale retrospective cohort study.International journal of colorectal disease · 2023Article
- Review on melanosis coli and anthraquinone-containing traditional Chinese herbs that cause melanosis coli.Frontiers in pharmacology · 2023Review
- Article
- Severe grade of melanosis coli is associated with a higher detection rate of colorectal adenoma.Journal of clinical biochemistry and nutrition · 2022Article
- Melanosis coli: A factor not associated with histological progression of colorectal polyps.Journal of digestive diseases · 2022Article
- Increased Colonic Fluorodeoxyglucose Uptake in Melanosis Coli-A Case Series of Three Patients.Gastro hep advances · 2022Article
- Melanosis Coli.JMA journal · 2021Article
- The Effects of Rhubarb for the Treatment of Diabetic Nephropathy in Animals: A Systematic Review and Meta-analysis.Frontiers in pharmacology · 2021Article
- Melanosis of the bladder: A rare diagnosis.Urology case reports · 2020Article
- Melanosis Coli Due to Aloe Vera Consumption.Internal medicine (Tokyo, Japan) · 2020Article
- Comparison between Diffusion-Weighted Sequences with Selective and Non-Selective Fat Suppression in the Evaluation of Crohn's Disease Activity: Are They Equally Useful?Diagnostics (Basel, Switzerland) · 2020Article
- Retrospective study on melanosis coli as risk factor of colorectal neoplasm: a 3-year colonoscopic finding in Zhuhai Hospital, China.International journal of colorectal disease · 2020Article
- Daiokanzoto (Da-Huang-Gan-Cao-Tang) is an effective laxative in gut microbiota associated with constipation.Scientific reports · 2019Article
- Melanosis Coli: A Helpful Contrast Effect or a Harmful Pigmentation?Clinical medicine insights. Gastroenterology · 2018Article
- Gender, age, and concomitant diseases of melanosis coli in China: a multicenter study of 6,090 cases.PeerJ · 2018Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUNDS AND
aimsThe association of melanosis coli with the development of colorectal polyps remains uncertain.
methodsFrom a total of 18263 patients who had received colonoscopy in our hospital, 219 with melanosis coli cases and 438 controls matched by age and sex (at 1:2 ratio) were included in this study. The association of incidence, number, location, and pathology of colorectal neoplasm with grades and distribution of melanosis coli were analyzed.
resultsMelanosis coli was associated with significantly more colorectal polyps than control, a higher incidence of numerous colorectal polyps (number ≥ 20) (7.3% vs 0.5%; p < 0.001), and higher number of small colorectal polyps (diameter ≤ 5 mm; p < 0.01). Patients with melanosis coli had higher incidences of low-grade adenomas (31.1% vs 23.3%, p < 0.05) and non-adenoma polyps (20.1% vs 12.8%, p < 0.05) than the controls. On multivariate analysis, melanosis coli was independently associated with increased detecting rates of low grade adenoma (OR = 1.54; 95%: 1.06-2.23; p < .05), non-adenoma polyp (OR = 1.72; 95%: 1.11-2.70; p < .05) and numerous polyps (OR = 16.2, 95%: 3.66-71.6; p < .05). There was no significant difference in the incidence of high-grade adenomas or adenocarcinomas in the two population groups, but the numbers of these lesions were insufficient to permit firm conclusions. No significant differences in incidence, number, and pathology of colorectal polyps between individuals with melanosis coli of three different grades of severity were found. Melanosis located predominantly in the right colon had an interestingly lower incidence of colonic polyps in right colon than did melanosis located predominantly in the left colon or total colon (8.9% vs. 26.3%, 24.0%, p < 0.05). Patients with melanosis coli had significantly more nonspecific distal ileal ulcers than did controls (8.0% vs 0%, p < 0.001).
conclusionMelanosis coli is associated with a higher incidence and number of colonic non-adenoma polyps and low-grade adenomas, and higher incidence of distal ileal ulcers. Melanosis coli may not be a harmless pigmentation, but a sign of chronic injury of colonic and intestinal mucosa.
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