Evidence map›Paper›PMID 29087815›Full record

ArticleJournal of studies on alcohol and drugs2017

Social Relationships Moderate Genetic Influences on Heavy Drinking in Young Adulthood.

Peter B Barr, Jessica E Salvatore, Hermine H Maes, Tellervo Korhonen, Antti Latvala, Fazil Aliev, Richard Viken, Richard J Rose, Jaakko Kaprio, Danielle M Dick

Abstract read
In one paragraph

Article in Journal of studies on alcohol and drugs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. High-Intensity Drinking in Adult Australian Twins.Alcoholism, clinical and experimental research · 2020
    Article
  10. Article
  11. FinnTwin12 Cohort: An Updated Review.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Review
  12. Article
  13. Romantic Partner Alcohol Misuse Interacts withJournal of contemporary criminal justice · 2019
    Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peter B BarrDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia.
Jessica E SalvatoreDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia.
Hermine H MaesVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Tellervo KorhonenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Antti LatvalaDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Fazil AlievVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Richard VikenDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana.
Richard J RoseDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana.
Jaakko KaprioDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Danielle M DickDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia.

Funding

The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Genetics, Romantic Relationships, and Alcohol Misuse in Emerging AdulthoodK01AA024152 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2016 to 2020
$741k
Genetically-informed designs of externalizing behavior and romantic relationshipsF32AA022269 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2013 to 2014
$113k
NIAAA NIH HHS F32 AA022269NIAAA NIH HHS K01 AA024152NIAAA NIH HHS K02 AA018755NIAAA NIH HHS R01 AA015416
6 · The paper itself

Abstract

objectiveSocial relationships, such as committed partnerships, limit risky behaviors like heavy drinking, in part, because of increased social control. The current analyses examine whether involvement in committed relationships or social support extend beyond a main effect to limit genetic liability in heavy drinking (gene-environment interaction) during young adulthood.

methodUsing data from the young adult wave of the Finnish Twin Study, FinnTwin12 (n = 3,269), we tested whether involvement in romantic partnerships or social support moderated genetic influences on heavy drinking using biometric twin modeling for gene-environment interaction.

resultsInvolvement in a romantic partnership was associated with a decline in genetic variance in both males and females, although the overall magnitude of genetic influence was greater in males. Sex differences emerged for social support: increased social support was associated with increased genetic influence for females and reduced genetic influence for males.

conclusionsThese findings demonstrate that social relationships are important moderators of genetic influences on young adult alcohol use. Mechanisms of social control that are important in limiting genetic liability during adolescence extend into young adulthood. In addition, although some relationships limit genetic liability equally, others, such as extensive social networks, may operate differently across sex.

Indexed as

Gene-Environment InteractionTwinsAdolescentAdultAlcohol DrinkingChildFemaleFinlandHumansMaleYoung Adult

Identifiers

PMID29087815
PMCPMC5668991

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.