Evidence map›Paper›PMID 29087442›Full record

ArticleAmerican journal of epidemiology2018

Intergenerational Transmission of Birth Weight Across 3 Generations.

Marius Lahti-Pulkkinen, Sohinee Bhattacharya, Katri Räikkönen, Clive Osmond, Jane E Norman, Rebecca M Reynolds

Abstract read
In one paragraph

Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Exploring the Fetal Origins Hypothesis Using Genetic Data.Social forces; a scientific medium of social study and interpretation · 2024
    Article
  5. Review
  6. Article
  7. Is there intergenerational continuity in early life experiences? Findings from the Harvard Study of Adult Development.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2023
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
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  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marius Lahti-PulkkinenUniversity/British Heart Foundation Center for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Sohinee BhattacharyaObstetric Epidemiology, Division of Applied Health Sciences, Dugald Baird Center for Research on Women's Health, University of Aberdeen, Aberdeen, United Kingdom.
Katri RäikkönenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Clive OsmondMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom.
Jane E NormanTommy's Center for Maternal and Fetal Health, Medical Research Unit, Center for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Rebecca M ReynoldsUniversity/British Heart Foundation Center for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

Funding

Medical Research Council MC_U147574242Medical Research Council MC_UP_A620_1016Medical Research Council MC_UU_12011/3Medical Research Council MC_UU_12011/4Medical Research Council MR/N022556/1
6 · The paper itself

Abstract

While previous studies have shown intergenerational transmission of birth weight from mother to child, whether the continuity persists across 3 generations has rarely been assessed. We used the Aberdeen Maternity and Neonatal Databank (United Kingdom) to examine the intergenerational correlations of birth weight, birth weight adjusted for gestational age and sex, and small- and large-for-gestational-age births across 3 generations among 1,457 grandmother-mother-child triads. All participants were born between 1950 and 2015. The intergenerational transmission was examined with linear regression analyses. We found that grandmaternal birth weight was associated with grandchild birth weight, independently of prenatal and sociodemographic covariates and maternal birth weight (B = 0.12 standard deviation units, 95% confidence interval: 0.07, 0.18). Similar intergenerational continuity was found for birth weight adjusted for sex and gestational age as well as for small-for-gestational-age births. In conclusion, birth weight and fetal growth showed intergenerational continuity across 3 generations. This supports the hypothesis that the developmental origins of birth weight and hence later health and disease are already present in earlier generations.

Indexed as

GrandparentsPedigreeBirth WeightDatabases, FactualFemaleFetal DevelopmentGestational AgeHumansInfant, NewbornMaleMothersRegression AnalysisUnited Kingdom

Identifiers

PMID29087442
PMCPMC5886358

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.