ArticleThe American journal of gastroenterology2017
Risk of Clostridium difficile Infection in Patients With Celiac Disease: A Population-Based Study.
Article in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- No Increased Risk of Hepatitis B Virus Infection in Patients with Celiac Disease: A Population-Based Study.Digestive diseases and sciences · 2025Article
- Vaccine Efficacy and Safety in Patients with Celiac Disease.Vaccines · 2024Review
- The Humoral Immune Response against Human Endogenous Retroviruses in Celiac Disease: A Case-Control Study.Biomedicines · 2024Article
- Anxiety and Associated Factors during the COVID-19 Pandemic Confinement in the Moroccan Adult Celiac Disease Population.Portuguese journal of public health · 2023Article
- Impact of Nutritional Profile on Gut Microbiota Diversity in Patients with Celiac Disease.Current microbiology · 2022Article
- Why are western diet and western lifestyle pro-inflammatory risk factors of celiac disease?Frontiers in nutrition · 2022Review
- The costs of celiac disease: a contingent valuation in Switzerland.The European journal of health economics : HEPAC : health economics in prevention and care · 2021Article
- Contribution of Infectious Agents to the Development of Celiac Disease.Microorganisms · 2021Review
- Gut microbiota, angiotensin-converting enzyme, celiac disease, and risk of COVID-19 infection: a review.Gastroenterology and hepatology from bed to bench · 2021Review
- COVID-19 pandemic perception in adults with celiac disease: an impulse to implement the use of telemedicine.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2020Article
- Celiac Disease and the Microbiome.Nutrients · 2019Review
- Hematologic Manifestations in Celiac Disease-A Practical Review.Medicina (Kaunas, Lithuania) · 2019Review
- Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study.Gut microbes · 2018Article
- Clostridioides difficile infection in dogs with chronic-recurring diarrhea responsive to dietary changes.Anaerobe · 2018Article
- Diagnostic challenges of celiac disease in a young child: A case report and a review of the literature.Medicine · 2018Review
- Stool PCR for Gastrointestinal Pathogens in Patients With and Without Immune-Mediated Intestinal Diseases.Digestive diseases and sciences · 2018Article
- Effect ofFrontiers in microbiology · 2018Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesPatients with celiac disease are at increased risk for infections such as tuberculosis, influenza, and pneumococcal pneumonia. However, little is known about the incidence of Clostridium difficile infection (CDI) in patients with celiac disease.
methodsWe identified patients with celiac disease based on intestinal biopsies submitted to all pathology departments in Sweden over a 39-year period (from July 1969 through February 2008). We compared risk of CDI (based on stratified Cox proportional hazards models) among patients with celiac disease vs. without celiac disease (controls) matched by age, sex, and calendar period.
resultsWe identified 28,339 patients with celiac disease and 141,588 controls; neither group had a history of CDI. The incidence of CDI was 56/100,000 person-years among patients with celiac disease and 26/100,000 person-years among controls, yielding an overall hazard ratio (HR) of 2.01 (95% confidence interval (CI), 1.64-2.47; P<0.0001). The risk of CDI was highest in the first 12 months after diagnosis of celiac disease (HR, 5.20; 95% CI, 2.81-9.62; P<0.0001), but remained high, compared to that of controls, 1-5 years after diagnosis (HR, 1.85; 95% CI, 1.22-2.81; P=0.004). Among 493 patients with CDI, antibiotic data were available for 251; there were no significant differences in prior exposures to antibiotics between patients with celiac disease and controls.
conclusionsIn a large population-based cohort study, patients with celiac disease had significantly higher incidence of CDI than controls. This finding is consistent with prior findings of higher rates of other infections in patients with celiac disease, and suggests the possibility of altered gut immunity and/or microbial composition in patients with celiac disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.