ArticleScientific data2017
The cell-type specific transcriptome in human adipose tissue and influence of obesity on adipocyte progenitors.
Article in Scientific data, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Aerobic glycolysis drives differentiation of unilocular adipocytes.Journal of lipid research · 2026Article
- Investigation into the molecular mechanism of obesity: an integrated approach of multi-omics analysis, machine learning and experimental validation.Journal of translational medicine · 2025Article
- Transcripts with high distal heritability mediate genetic effects on complex metabolic traits.Nature communications · 2025Article
- Transcriptome Analysis Reveals Norathyriol Prolongs the Lifespan via Regulating Metabolism inMetabolites · 2024Article
- IL-1β promotes adipogenesis by directly targeting adipocyte precursors.Nature communications · 2024Article
- Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts.Nature communications · 2024Article
- TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction.Nature communications · 2024Article
- Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M.Cell reports. Medicine · 2024Article
- Single cell full-length transcriptome of human subcutaneous adipose tissue reveals unique and heterogeneous cell populations.iScience · 2022Article
- The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development.Science advances · 2022Article
- Mitochondrial regulation and white adipose tissue homeostasis.Trends in cell biology · 2022Review
- Shared genetic loci for body fat storage and adipocyte lipolysis in humans.Scientific reports · 2022Article
- Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease.eLife · 2021Article
- A Novel Hypothesis and Characterization to Isolate Microvascular Endothelial Cells Simultaneously with Adipose-Derived Stem Cells from the Human Adipose-Derived Stromal Vascular Fraction.Tissue engineering and regenerative medicine · 2021Article
- Putative positive role of inflammatory genes in fat deposition supported by altered gene expression in purified human adipocytes and preadipocytes from lean and obese adipose tissues.Journal of translational medicine · 2020Article
- The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance.PLoS genetics · 2020Article
- Adipose tissue in health and disease through the lens of its building blocks.Scientific reports · 2020Article
- Article
- Single-cell analysis of human adipose tissue identifies depot and disease specific cell types.Nature metabolism · 2020Article
- Fibroblast activation protein restrains adipogenic differentiation and regulates matrix-mediated mTOR signaling.Matrix biology : journal of the International Society for Matrix Biology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity affects gene expression and metabolism of white adipose tissue (WAT), which results in insulin resistance (IR) and type 2 diabetes. However, WAT is a heterogeneous organ containing many cell types that might respond differently to obesity-induced changes. We performed flow cytometry sorting and RNA expression profiling by microarray of major WAT cell types (adipocytes, CD45-/CD31-/CD34+ progenitors, CD45+/CD14+ monocytes/ macrophages, CD45+/CD14- leukocytes), which allowed us to identify genes enriched in specific cell fractions. Additionally, we included adipocytes and adipocyte progenitor cells obtained from lean and obese individuals. Taken together, we provide a detailed gene expression atlas of major human adipose tissue resident cell types for clinical/basic research and using this dataset provide lists of cell-type specific genes that are of interest for metabolic research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.