Evidence map›Paper›PMID 29087338›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Protocadherin

Kerry M Goodman, Rotem Rubinstein, Hanbin Dan, Fabiana Bahna, Seetha Mannepalli, Göran Ahlsén, Chan Aye Thu, Rosemary V Sampogna, Tom Maniatis, Barry Honig and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Structural Insights into Ordered Multicomponent Assemblies in Cell Junctions.Advances in experimental medicine and biology · 2026
    Review
  5. Article
  6. Surface delivery quantification reveals distinct trafficking efficiencies among clustered protocadherin isoforms.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Clustered protocadherinProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Visualization ofiScience · 2023
    Article
  13. Article
  14. Article
  15. Structure and evolution of neuronal wiring receptors and ligands.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Review
  16. Article
  17. On the formation of ordered protein assemblies in cell-cell interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kerry M GoodmanDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Rotem RubinsteinDepartment of Systems Biology, Columbia University, New York, NY 10032.
Hanbin DanDepartment of Systems Biology, Columbia University, New York, NY 10032.
Fabiana BahnaZuckerman Mind Brain and Behavior Institute, Columbia University, New York, NY 10027.
Seetha MannepalliDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Göran AhlsénZuckerman Mind Brain and Behavior Institute, Columbia University, New York, NY 10027.
Chan Aye ThuDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Rosemary V SampognaDepartment of Medicine, Columbia University, New York, NY 10032.
Tom ManiatisDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032; tm2472@cumc.columbia.edu bh6@cumc.columbia.edu lss8@columbia.edu.
Barry HonigDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032; tm2472@cumc.columbia.edu bh6@cumc.columbia.edu lss8@columbia.edu.
Lawrence ShapiroDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032; tm2472@cumc.columbia.edu bh6@cumc.columbia.edu lss8@columbia.edu.

Funding

Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
The structural basis of cis and trans protocadherin interactionsR01MH114817 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P, SHAPIRO, LAWRENCE S · 2017 to 2021
$2.4M
High-performance compute cluster for biomedical computingS10OD012351 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA · 2012 to 2012
$2.0M
The structural basis of cis and trans protocadherin interactionsR01GM107571 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P, SHAPIRO, LAWRENCE S · 2013 to 2016
$1.8M
Circadian clock regulation of branching morphogenesis during kidney developmentR01DK106548 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SAMPOGNA, ROSEMARY V · 2016 to 2020
$1.8M
Storage System for High Performance ComputingS10OD021764 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA · 2016 to 2016
$600k
Howard Hughes Medical InstituteNIDDK NIH HHS R01 DK106548NIGMS NIH HHS P41 GM103403NIGMS NIH HHS R01 GM107571NIH HHS S10 OD012351NIH HHS S10 OD021764NIMH NIH HHS R01 MH114817
6 · The paper itself

Abstract

Clustered protocadherins (Pcdhs) mediate numerous neural patterning functions, including neuronal self-recognition and non-self-discrimination to direct self-avoidance among vertebrate neurons. Individual neurons stochastically express a subset of Pcdh isoforms, which assemble to form a stochastic repertoire of

Indexed as

Protein DomainsProtein Interaction Domains and MotifsAmino Acid SequenceAnimalsCadherinsCrystallography, X-RayHEK293 CellsHumansMiceModels, MolecularMutagenesis, Site-DirectedNeuronsProtein IsoformsProtein MultimerizationSequence AlignmentSequence Analysis, ProteinCadherinsProtein Isoformsclustered protocadherincrystal structureneuronal self-avoidanceprotein–protein interactionself-recognition

Identifiers

PMID29087338
PMCPMC5699079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.