Evidence map›Paper›PMID 29087313›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Relevance of iPSC-derived human PGC-like cells at the surface of embryoid bodies to prechemotaxis migrating PGCs.

Shino Mitsunaga, Junko Odajima, Shiomi Yawata, Keiko Shioda, Chie Owa, Kurt J Isselbacher, Jacob H Hanna, Toshi Shioda

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. In vitro models of the male reproductive system: applications for developmental and reproductive toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. HMGXB4 TargetsInternational journal of molecular sciences · 2023
    Article
  11. Article
  12. Article
  13. Modeling Human Gonad Development in Organoids.Tissue engineering and regenerative medicine · 2022
    Article
  14. Emerging Roles of NANOS RNA-Binding Proteins in Cancer.International journal of molecular sciences · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Shino MitsunagaMassachusetts General Hospital Center for Cancer Research and Harvard Medical School, Charlestown, MA 02129.
Junko OdajimaMassachusetts General Hospital Center for Cancer Research and Harvard Medical School, Charlestown, MA 02129.
Shiomi YawataMassachusetts General Hospital Center for Cancer Research and Harvard Medical School, Charlestown, MA 02129.
Keiko ShiodaMassachusetts General Hospital Center for Cancer Research and Harvard Medical School, Charlestown, MA 02129.
Chie OwaMassachusetts General Hospital Center for Cancer Research and Harvard Medical School, Charlestown, MA 02129.
Kurt J IsselbacherMassachusetts General Hospital Center for Cancer Research and Harvard Medical School, Charlestown, MA 02129; kisselbacher@mgh.harvard.edu tshioda@mgh.harvard.edu.ORCID 0000-0002-8527-5120
Jacob H HannaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.ORCID 0000-0003-2042-9974
Toshi ShiodaMassachusetts General Hospital Center for Cancer Research and Harvard Medical School, Charlestown, MA 02129; kisselbacher@mgh.harvard.edu tshioda@mgh.harvard.edu.ORCID 0000-0002-9434-7835
Harvard University · USWeizmann Institute of Science · IL

Funding

Transgenerational obesity caused by ancestral exposure to obesogens in utero: changes in germline genomic architecture, roles of gonadal somatic cells, and metabolomic analysis of sexual dimorphismR01ES023316 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE BLUMBERG, TOSHIHIRO SHIODA · 2013 to 2026
$8.3M
Roles of Nuclear Receptors in Generation of Heritable Epimutations in Germ CellsR21ES024861 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI SHIODA, TOSHIHIRO · 2015 to 2016
$471k
NIEHS NIH HHS R01 ES023316NIEHS NIH HHS R21 ES024861
6 · The paper itself

Abstract

Pluripotent stem cell-derived human primordial germ cell-like cells (hPGCLCs) provide important opportunities to study primordial germ cells (PGCs). We robustly produced CD38

Indexed as

Gene Expression Regulation, DevelopmentalADP-ribosyl Cyclase 1Cell AggregationCell DifferentiationCell MovementChemokine CXCL12ChemokinesDNA-Binding ProteinsEmbryoid BodiesEmbryo, MammalianGene Expression ProfilingGenes, HomeoboxGerm CellsHumansInduced Pluripotent Stem CellsOctamer Transcription Factor-3ADP-ribosyl Cyclase 1Chemokine CXCL12ChemokinesCXCL12 protein, humanCXCR4 protein, humanDNA-Binding ProteinsNANOS3 protein, humanOctamer Transcription Factor-3Positive Regulatory Domain I-Binding Factor 1POU5F1 protein, humanPRDM1 protein, humanReceptors, CXCR4Repressor ProteinsRNA-Binding ProteinsRREB1 protein, humanSOX17 protein, humanSOXF Transcription FactorsTFAP2C protein, humanTranscription Factor AP-2Transcription Factorsembryoid bodyinduced pluripotent stem cellsPRDM1primordial germ cellsTFAP2C

Identifiers

PMID29087313
PMCPMC5699045
OpenAlexW2765162962

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.