ArticleProceedings of the National Academy of Sciences of the United States of America2017
Using neurostimulation to understand the impact of pre-morbid individual differences on post-lesion outcomes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Can transcranial photobiomodulation improve cognitive function in TBI patients? A systematic review.Frontiers in psychology · 2024Pooled it
- The Impact of Transcranial Magnetic Stimulation on Reading Processes: A Systematic Review.Neuropsychology review · 2023Pooled it
- Addressing the theory crisis in statistical learning research.NPJ science of learning · 2025Review
- Distinct parallel activation and interaction between dorsal and ventral pathways during phonological and semantic processing: A cTBS-fMRI study.Human brain mapping · 2024Article
- Advances in photobiomodulation for cognitive improvement by near-infrared derived multiple strategies.Journal of translational medicine · 2023Review
- Neuromodulatory effects of transcranial magnetic stimulation on language performance in healthy participants: Systematic review and meta-analysis.Frontiers in human neuroscience · 2022Article
- Category-selective deficits are the exception and not the rule: Evidence from a case-series of 64 patients with ventral occipito-temporal cortex damage.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- The neural and neurocomputational bases of recovery from post-stroke aphasia.Nature reviews. Neurology · 2020Review
- The visual word form area (VWFA) is part of both language and attention circuitry.Nature communications · 2019Article
- The Ventral Anterior Temporal Lobe has a Necessary Role in Exception Word Reading.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neuropsychological data have proven invaluable in advancing our understanding of higher cognition. The interpretation of such data is, however, complicated by the fact that post-lesion behavioral abnormalities could reflect pre-morbid individual differences in the cognitive domain of interest. Here we exploited the virtual lesion methodology offered by transcranial magnetic stimulation (TMS) to explore the impact of pre-morbid individual differences on post-lesion performance. We applied this approach to the domain of reading, a crucial ability in which there are known to be considerable individual differences in the normal population. As predicted by neuropsychological studies of surface dyslexia in semantic dementia and the connectionist triangle model of reading, previous empirical work has shown that healthy participants vary in their reliance on meaning for reading words with atypical correspondences between spelling and sound. We therefore selected participants who varied along this dimension and applied a virtual lesion to the left anterior temporal lobe. As expected, we observed a significant three-way interaction between "pre-morbid" reading status, stimulation, and word type, such that TMS increased the disadvantage for spelling-sound atypical words more for the individuals with stronger semantic reliance. This successful test-case study provides an approach to understanding the impact of pre-morbid individual variation on post-lesion outcomes that could be fruitfully applied to a variety of cognitive domains.
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