ArticleProceedings of the National Academy of Sciences of the United States of America2017
Intercellular competition and the inevitability of multicellular aging.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 105 citations in OpenAlex.
- How and why does aging occur? Updating evolutionary theory to meet a new era of data.Evolution, medicine, and public health · 2026Article
- Fisher Information and the Dynamics of Multicellular Ageing.Entropy (Basel, Switzerland) · 2025Article
- Molecular and Functional Convergences Associated with Complex Multicellularity in Eukarya.Molecular biology and evolution · 2025Article
- Agelessness is possible under the disposable soma theory but system complexity makes it unlikely.Journal of theoretical biology · 2024Article
- An expanded view of cell competition.Development (Cambridge, England) · 2024Review
- The Warburg Effect is the result of faster ATP production by glycolysis than respiration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The brain-body energy conservation model of aging.Nature aging · 2024Review
- Cell autocloning as a pathway to their real rejuvenation.Frontiers in aging · 2024Article
- Revisiting Nature's "Unifying Patterns": A Biological Appraisal.Biomimetics (Basel, Switzerland) · 2023Review
- Is Aging an Inevitable Characteristic of Organic Life or an Evolutionary Adaptation?Biochemistry. Biokhimiia · 2022Review
- We are all aging, and here's why.Aging medicine (Milton (N.S.W)) · 2022Review
- Toward a theory of evolution as multilevel learning.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Simplifying the Process of Going From Cells to Tissues Using Statistical Mechanics.Frontiers in physiology · 2022Article
- Antagonistic pleiotropy and the evolution of extraordinary lifespans in eusocial organisms.Evolution letters · 2021Article
- Does Cancer Biology Rely on Parrondo's Principles?Cancers · 2021Review
- Asymmetry, division of labour and the evolution of ageing in multicellular organisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- The Hematopoietic Bone Marrow Niche Ecosystem.Frontiers in cell and developmental biology · 2021Review
- Hierarchical analysis of ontogenetic time to describe heterochrony and taxonomy of developmental stages.Scientific reports · 2020Article
- Autofluorescence-based sorting removes senescent cells from mesenchymal stromal cell cultures.Scientific reports · 2020Article
- Biomarkers for Aging Identified in Cross-sectional Studies Tend to Be Non-causative.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Current theories attribute aging to a failure of selection, due to either pleiotropic constraints or declining strength of selection after the onset of reproduction. These theories implicitly leave open the possibility that if senescence-causing alleles could be identified, or if antagonistic pleiotropy could be broken, the effects of aging might be ameliorated or delayed indefinitely. These theories are built on models of selection between multicellular organisms, but a full understanding of aging also requires examining the role of somatic selection within an organism. Selection between somatic cells (i.e., intercellular competition) can delay aging by purging nonfunctioning cells. However, the fitness of a multicellular organism depends not just on how functional its individual cells are but also on how well cells work together. While intercellular competition weeds out nonfunctional cells, it may also select for cells that do not cooperate. Thus, intercellular competition creates an inescapable double bind that makes aging inevitable in multicellular organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.