Evidence map›Paper›PMID 29087293›Full record

ArticleeLife2017

The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline.

Alexis S Bailey, Pedro J Batista, Rebecca S Gold, Y Grace Chen, Dirk G de Rooij, Howard Y Chang, Margaret T Fuller

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 2 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 2 syntheses or guidelines pooled it, 210 citations in OpenAlex.

  1. Emerging Roles of mFrontiers in oncology · 2022
    Pooled it
  2. Pooled it
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  5. Emerging roles of mJournal of assisted reproduction and genetics · 2026
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  9. Review
  10. RNA modification systems as therapeutic targets.Nature reviews. Drug discovery · 2026
    Review
  11. Review
  12. Article
  13. Article
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  15. Article
  16. mEpigenomes · 2025
    Review
  17. Article
  18. Characteristic analysis of NBMC genomics · 2025
    Article
  19. Article
  20. Article

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Alexis S Bailey *Department of Developmental Biology, Stanford University School of Medicine, Stanford, United States.ORCID http://orcid.org/0000-0001-8838-8625
Pedro J Batista *Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, United States.ORCID http://orcid.org/0000-0003-1055-2354
Rebecca S GoldDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, United States.ORCID http://orcid.org/0000-0002-2408-7716
Y Grace ChenCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, United States.ORCID http://orcid.org/0000-0003-3574-5734
Dirk G de RooijCenter for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0003-3932-4419
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, United States.ORCID http://orcid.org/0000-0002-9459-4393
Margaret T FullerDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, United States.ORCID http://orcid.org/0000-0002-3804-4987
Stanford University · USAmsterdam UMC Location University of Amsterdam · NL

Funding

Structural Motifs in RNAR01HG004361 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2007 to 2018
$4.7M
TRAINING IN NEONATAL BIOLOGYT32HD007249 · NICHD · STANFORD UNIVERSITY · PI STEVENSON, DAVID K · 1985 to 2013
$4.4M
Stanford University Center for Reproductive and Stem Cell biologyP50HD068158 · NICHD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2014 to 2015
$3.3M
Genetics and Developmental Biology Training ProgramT32GM141828 · NIGMS · STANFORD UNIVERSITY · PI MARGARET T FULLER, Gavin J Sherlock · 2022 to 2026
$2.6M
Conserved regulation of the switch from proliferation to differentiation in the germ line stem cell lineageR01GM122951 · NIGMS · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2018 to 2020
$956k
NHGRI NIH HHS R01 HG004361NICHD NIH HHS P50 HD068158NICHD NIH HHS T32 HD007249NIGMS NIH HHS R01 GM122951NIGMS NIH HHS T32 GM141828
6 · The paper itself

Abstract

The switch from mitosis to meiosis is the key event marking onset of differentiation in the germline stem cell lineage. In

Indexed as

Cell DifferentiationCell ProliferationAnimalsGene Expression RegulationGerm CellsMeiosisMiceMitosisProtein BindingRNA HelicasesRNA HelicasesYthdc2 protein, mouseBgcndevelopmental biologygermline stem cell lineagemitosis to meiosis transitionmousepost-transcriptional regulationspermatogenesisstem cellsYTHDC2

Identifiers

PMID29087293
PMCPMC5703642
OpenAlexW2765787092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.