Evidence map›Paper›PMID 29087238›Full record

ArticleRadiology2018

Effects of Career Duration, Concussion History, and Playing Position on White Matter Microstructure and Functional Neural Recruitment in Former College and Professional Football Athletes.

Michael D Clark, Eleanna M L Varangis, Allen A Champagne, Kelly S Giovanello, Feng Shi, Zachary Y Kerr, J Keith Smith, Kevin M Guskiewicz

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04263337 (Neurologic Function Across the Lifespan), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04263337 phase1active not recruitingnot on this mapstarted 2020, after this paper: background citation

Neurologic Function Across the Lifespan: A Prospective, LONGitudinal, and Translational Study for Former National Football League Players

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2020 to 2028Enrolled250ConditionsConcussion, BrainArms[11C] PiB, [18F] PBR111, [18F] Flortaucipir
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  9. The association between playing professional American football and longevity.Proceedings of the National Academy of Sciences of the United States of America · 2023
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  12. Review
  13. Observational
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  19. Changes in volumetric and metabolic parameters relate to differences in exposure to sub-concussive head impacts.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Michael D ClarkFrom the Departments of Exercise and Sport Science (M.D.C., Z.Y.K., K.M.G.), Psychology and Neuroscience (E.M.L.V., K.S.G.), and Radiology (J.K.S.), University of North Carolina at Chapel Hill, 209 Fetzer Hall, CB 8700, Chapel Hill, NC 27599; Centre for Neuroscience Studies, Queen's University, Kingston, Ont, Canada (A.A.C.); and Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (F.S.).ORCID 0000-0002-5019-0290
Eleanna M L VarangisFrom the Departments of Exercise and Sport Science (M.D.C., Z.Y.K., K.M.G.), Psychology and Neuroscience (E.M.L.V., K.S.G.), and Radiology (J.K.S.), University of North Carolina at Chapel Hill, 209 Fetzer Hall, CB 8700, Chapel Hill, NC 27599; Centre for Neuroscience Studies, Queen's University, Kingston, Ont, Canada (A.A.C.); and Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (F.S.).
Allen A ChampagneFrom the Departments of Exercise and Sport Science (M.D.C., Z.Y.K., K.M.G.), Psychology and Neuroscience (E.M.L.V., K.S.G.), and Radiology (J.K.S.), University of North Carolina at Chapel Hill, 209 Fetzer Hall, CB 8700, Chapel Hill, NC 27599; Centre for Neuroscience Studies, Queen's University, Kingston, Ont, Canada (A.A.C.); and Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (F.S.).
Kelly S GiovanelloFrom the Departments of Exercise and Sport Science (M.D.C., Z.Y.K., K.M.G.), Psychology and Neuroscience (E.M.L.V., K.S.G.), and Radiology (J.K.S.), University of North Carolina at Chapel Hill, 209 Fetzer Hall, CB 8700, Chapel Hill, NC 27599; Centre for Neuroscience Studies, Queen's University, Kingston, Ont, Canada (A.A.C.); and Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (F.S.).
Feng ShiFrom the Departments of Exercise and Sport Science (M.D.C., Z.Y.K., K.M.G.), Psychology and Neuroscience (E.M.L.V., K.S.G.), and Radiology (J.K.S.), University of North Carolina at Chapel Hill, 209 Fetzer Hall, CB 8700, Chapel Hill, NC 27599; Centre for Neuroscience Studies, Queen's University, Kingston, Ont, Canada (A.A.C.); and Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (F.S.).
Zachary Y KerrFrom the Departments of Exercise and Sport Science (M.D.C., Z.Y.K., K.M.G.), Psychology and Neuroscience (E.M.L.V., K.S.G.), and Radiology (J.K.S.), University of North Carolina at Chapel Hill, 209 Fetzer Hall, CB 8700, Chapel Hill, NC 27599; Centre for Neuroscience Studies, Queen's University, Kingston, Ont, Canada (A.A.C.); and Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (F.S.).
J Keith SmithFrom the Departments of Exercise and Sport Science (M.D.C., Z.Y.K., K.M.G.), Psychology and Neuroscience (E.M.L.V., K.S.G.), and Radiology (J.K.S.), University of North Carolina at Chapel Hill, 209 Fetzer Hall, CB 8700, Chapel Hill, NC 27599; Centre for Neuroscience Studies, Queen's University, Kingston, Ont, Canada (A.A.C.); and Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (F.S.).
Kevin M GuskiewiczFrom the Departments of Exercise and Sport Science (M.D.C., Z.Y.K., K.M.G.), Psychology and Neuroscience (E.M.L.V., K.S.G.), and Radiology (J.K.S.), University of North Carolina at Chapel Hill, 209 Fetzer Hall, CB 8700, Chapel Hill, NC 27599; Centre for Neuroscience Studies, Queen's University, Kingston, Ont, Canada (A.A.C.); and Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, Calif (F.S.).

Funding

The Role of Repetitive Head Trauma on Cognitive Decline and Fronto-limbic Functional ConnectivityF30NS090816 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CLARK, MICHAEL DAVID · 2015 to 2018
$143k
NINDS NIH HHS F30 NS090816
6 · The paper itself

Abstract

Purpose To better understand the relationship between exposure to concussive and subconcussive head impacts, white matter integrity, and functional task-related neural activity in former U.S. football athletes. Materials and Methods Between 2011 and 2013, 61 cognitively unimpaired former collegiate and professional football players (age range, 52-65 years) provided informed consent to participate in this cross-sectional study. Participants were stratified across three crossed factors: career duration, concussion history, and primary playing position. Fractional anisotropy (FA) and blood oxygen level-dependent (BOLD) percent signal change (PSC) were measured with diffusion-weighted and task-related functional magnetic resonance imaging, respectively. Analyses of variance of FA and BOLD PSC were used to determine main or interaction effects of the three factors. Results A significant interaction between career duration and concussion history was observed; former college players with more than three concussions had lower FA in a broadly distributed area of white matter compared with those with zero to one concussion (t29 = 2.774; adjusted P = .037), and the opposite was observed for former professional players (t29 = 3.883; adjusted P = .001). A separate interaction between concussion history and position was observed: Nonspeed players with more than three concussions had lower FA in frontal white matter compared with those with zero to one concussion (t25 = 3.861; adjusted P = .002). Analysis of working memory-task BOLD PSC revealed a similar interaction between concussion history and position (all adjusted P < .004). Overall, former players with lower FA tended to have lower BOLD PSC across three levels of a working memory task. Conclusion Career duration and primary playing position seem to modify the effects of concussion history on white matter structure and neural recruitment. The differences in brain structure and function were observed in the absence of clinical impairment, which suggested that multimodal imaging may provide early markers of onset of traumatic neurodegenerative disease.

Indexed as

Brain ConcussionDiffusion Magnetic Resonance ImagingFootballHumansMagnetic Resonance ImagingMaleMemory, Short-TermMental DisordersMental Status and Dementia TestsMiddle AgedNeuropsychological TestsOxygenRecruitment, NeurophysiologicalTime FactorsWhite MatterOxygen

Identifiers

PMID29087238
PMCPMC5834225

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.