ArticleACS chemical biology2017
Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.
Article in ACS chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Characterization of Variation in Natural Product Production Under Chemical Elicitation Using Parallel Stable Isotope Labeling.ACS chemical biology · 2025Article
- NarL gene modulates the host lipid metabolism for survival of Salmonella Typhimurium in murine macrophages.Molecular biology reports · 2025Article
- Structural basis of transcriptional regulation by UrtR in response to uric acid.Nucleic acids research · 2024Article
- Bioactive exometabolites drive maintenance competition in simple bacterial communities.mSystems · 2024Article
- Article
- A membrane protein of the rice pathogen Burkholderia glumae required for oxalic acid secretion and quorum sensing.Molecular plant pathology · 2023Article
- Transcription Factor PecS MediatesJournal of bacteriology · 2023Article
- Whole-Cell MALDI-ToF MS Coupled with Untargeted Metabolomics Facilitates Investigations of Microbial Chemical Interactions.Chembiochem : a European journal of chemical biology · 2023Article
- Article
- Lactonase-mediated inhibition of quorum sensing largely alters phenotypes, proteome, and antimicrobial activities inFrontiers in cellular and infection microbiology · 2023Article
- The Global Regulator MftR Controls Virulence and Siderophore Production in Burkholderia thailandensis.Journal of bacteriology · 2022Article
- The NarX-NarL two-component system regulates biofilm formation, natural product biosynthesis, and host-associated survival in Burkholderia pseudomallei.Scientific reports · 2022Article
- Extracytoplasmic Function Sigma Factors Governing Production of the Primary Siderophores in PathogenicFrontiers in microbiology · 2022Review
- A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters.Annual review of biochemistry · 2021Review
- Nitrate- and Nitrite-Sensing Histidine Kinases: Function, Structure, and Natural Diversity.International journal of molecular sciences · 2021Review
- Secondary metabolites from the Burkholderia pseudomallei complex: structure, ecology, and evolution.Journal of industrial microbiology & biotechnology · 2020Review
- Article
- Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites?Antibiotics (Basel, Switzerland) · 2019Review
- The Link between Purine Metabolism and Production of Antibiotics inAntibiotics (Basel, Switzerland) · 2019Review
- Burkholderia thailandensis strain E555 is a surrogate for the investigation of Burkholderia pseudomallei replication and survival in macrophages.BMC microbiology · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Many bacteria encode biosynthetic proteins that produce a vast array of natural products. These compounds are often synthesized during host invasion as they function as virulence factors. In addition, such secondary metabolites have yielded numerous molecular scaffolds with pharmaceutical and clinical importance. The gene clusters that encode proteins responsible for synthesis of these compounds are typically silenced or "cryptic" under laboratory growth conditions, hampering discovery of novel lead compounds. We report here that MftR is a global repressor of secondary metabolite synthesis in Burkholderia thailandensis and that urate functions as a physiologically relevant inducer of gene expression. Biosynthetic gene clusters under MftR control include those associated with production of the antimicrobial bactobolins, the iron siderophore malleobactin, and the virulence factor malleilactone. MftR also controls additional genes associated with survival in a host environment, such as genes encoding components of the type III secretion system (T3SS) and proteins linked to anaerobic respiration. This observation not only has implications for understanding activation of gene regulatory networks during host invasion, but it also paves the way for isolation of novel therapeutic leads.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.