Evidence map›Paper›PMID 29086862›Full record

ArticleChemistry Central journal2017

Comprehensive spectral identification of key intermediates to the final product of the chiral pool synthesis of radezolid.

Katarzyna Michalska, Elżbieta Bednarek, Ewa Gruba, Kornelia Lewandowska, Mikołaj Mizera, Judyta Cielecka-Piontek

Open access · goldAbstract read
In one paragraph

Article in Chemistry Central journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Katarzyna MichalskaDepartment of Antibiotics and Microbiology, National Medicines Institute, Chelmska 30/34, 00-725, Warsaw, Poland. k.michalska@nil.gov.pl.
Elżbieta BednarekDepartment of Counterfeit Medicinal Products and Drugs, National Medicines Institute, Chelmska 30/34, 00-725, Warsaw, Poland. e.bednarek@nil.gov.pl.
Ewa GrubaDepartment of Antibiotics and Microbiology, National Medicines Institute, Chelmska 30/34, 00-725, Warsaw, Poland.
Kornelia LewandowskaDepartment of Molecular Crystals, Institute of Molecular Physics of the Polish Academy of Sciences, Smoluchowskiego 17, 60-179, Poznan, Poland.
Mikołaj MizeraDepartment of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland.
Judyta Cielecka-PiontekDepartment of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland. judyta.piontek@ump.edu.pl.
Narodowy Instytut Leków · PLPoznan University of Medical Sciences · PLPolish Academy of Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radezolid (RAD, 12), biaryl oxazolidinone, was synthesised with small modifications according to the methods described in the literature. The pharmacological activity is observed only for (S)-enantiomer, therefore its synthesis is oriented towards obtaining a single isomer of required purity and desired optical configuration. The intermediate products of RAD synthesis were characterised using

Identifiers

PMID29086862
PMCPMC5549672
OpenAlexW2742443379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.