Evidence map›Paper›PMID 29086496›Full record

ReviewObesity (Silver Spring, Md.)2018

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.

Stephen D Anton, Keelin Moehl, William T Donahoo, Krisztina Marosi, Stephanie A Lee, Arch G Mainous, Christiaan Leeuwenburgh, Mark P Mattson

7 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Obesity (Silver Spring, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 363 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
363citing papers in PubMed, 12 pooled it
22.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05126199 naunknown statusnot on this mapstarted 2021, after this paper: background citation

The Effect of Time-restricted Eating on Insulin Levels and Other Metabolic Abnormalities in Polycystic Ovarian Syndrome: A Randomised Feasibility Study of Real-world Clinical Advice

TypeinterventionalSponsorRuairí FloydRan2021 to 2023Enrolled20ConditionsPCOS, Hyperinsulinemia, Insulin ResistanceArmsTime restricted eating, Normal ad libitum diet
NCT05236127 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effect of Intermittent Fasting on Acute Subconcussive Head Impacts

TypeinterventionalSponsorIndiana UniversityRan2022 to 2022Enrolled40ConditionsSports Injury, Intermittent FastingArmsSoccer Heading, Intermittent Fasting
NCT05482711 nacompletednot on this mapstarted 2023, after this paper: background citation

Assessment of Fuel Utilization and Circadian Rhythms in Overweight, Older Adults Following Time Restricted Eating - Phase 2 (FAR Phase 2)

TypeinterventionalSponsorUniversity of FloridaRan2023 to 2026Enrolled15ConditionsAgingArmsTime Restricted Eating Intervention
NCT05590247 nacompletednot on this mapstarted 2022, after this paper: background citation

Role of Intermittent Fasting on Disease Severity and Quality of Life in Psoriasis and Psoriatic Arthritis

TypeinterventionalSponsorOhio State UniversityRan2022 to 2025Enrolled60ConditionsPsoriasis, Psoriatic ArthritisArmsIntermittent Fasting Diet
NCT05732935 nacompletednot on this mapstarted 2023, after this paper: background citation

Fasting to Provide Energy Needed to Help Adults in Need of Cognitive Enhancement (FASTING ENHANCE)

TypeinterventionalSponsorUniversity of FloridaRan2023 to 2026Enrolled45ConditionsOverweight and Obesity, Time Restricted Feeding, Alzheimer DiseaseArmsTime Restricted Eating intervention, Successful Aging Comparison Group (LEARN)
NCT06429124 narecruitingnot on this mapstarted 2023, after this paper: background citation

Time-Restricted Eating in Alzheimer's Disease : The T.R.E.A.D Trial

TypeinterventionalSponsorSt. Joseph's Hospital and Medical Center, PhoenixRan2023 to 2026Enrolled30ConditionsMild Cognitive Impairment (MCI)ArmsDietary Intervention
NCT07189637 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Combined Effect of the Mediterranean Diet and Intermittent Fasting on Hypertension

TypeinterventionalSponsorNadide Gizem Tarakci FilizRan2025 to 2026Enrolled48ConditionsHypertensionArmsFace-to-face nutrition education, Intermittent Fasting Diet, Mediterranean Diet
3 · Its place in the literature

Who cites it

363 citing papers in PubMed, 12 syntheses or guidelines pooled it, 734 citations in OpenAlex.

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303 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Stephen D AntonDepartment of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, Florida, USA.ORCID 0000-0001-5020-5280
Keelin MoehlLaboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA.
William T DonahooDivision of Endocrinology, Diabetes and Metabolism, College of Medicine, University of Florida, Gainesville, Florida, USA.
Krisztina MarosiLaboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA.
Stephanie A LeeDepartment of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, Florida, USA.
Arch G MainousDepartment of Health Services Research, Management and Policy, University of Florida, Gainesville, Florida, USA.
Christiaan LeeuwenburghDepartment of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, Florida, USA.
Mark P MattsonLaboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA.
University of Florida Health · USInstitute on Aging · USJohns Hopkins University · USUniversity of Florida · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG028740
6 · The paper itself

Abstract

objectiveIntermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can range from 12 hours to several days, on a recurring basis. This review is focused on the physiological responses of major organ systems, including the musculoskeletal system, to the onset of the metabolic switch: the point of negative energy balance at which liver glycogen stores are depleted and fatty acids are mobilized (typically beyond 12 hours after cessation of food intake). RESULTS AND

conclusionsEmerging findings suggest that the metabolic switch from glucose to fatty acid-derived ketones represents an evolutionarily conserved trigger point that shifts metabolism from lipid/cholesterol synthesis and fat storage to mobilization of fat through fatty acid oxidation and fatty acid-derived ketones, which serve to preserve muscle mass and function. Thus, IF regimens that induce the metabolic switch have the potential to improve body composition in overweight individuals. Moreover, IF regimens also induce the coordinated activation of signaling pathways that optimize physiological function, enhance performance, and slow aging and disease processes. Future randomized controlled IF trials should use biomarkers of the metabolic switch (e.g., plasma ketone levels) as a measure of compliance and of the magnitude of negative energy balance during the fasting period.

Indexed as

EatingEnergy IntakeFastingFeeding BehaviorHumans

Identifiers

PMID29086496
PMCPMC5783752
OpenAlexW2766781761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.