ReviewJournal of diabetes investigation2018
Molecular mechanism of obesity-induced 'metabolic' tissue remodeling.
Review in Journal of diabetes investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Effects of Exercise on Extracellular Vesicles in Patients with Metabolic Dysfunction: a Systematic Review.Journal of cardiovascular translational research · 2023Pooled it
- RNA-Binding Proteins in Adipose Biology: From Mechanistic Understanding to Therapeutic Opportunities.International journal of molecular sciences · 2026Review
- Mapping lipid species remodeling in high fat diet-fed mice: Unveiling adipose tissue dysfunction with Raman microspectroscopy.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2024Article
- Is the βBiomolecules · 2023Review
- Metabolic Associated Fatty Liver Disease (MAFLD) and COVID-19 Infection: An Independent Predictor of Poor Disease Outcome?Medicina (Kaunas, Lithuania) · 2023Observational
- Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques.Mucosal immunology · 2022Article
- Butyric acid alleviated chronic intermittent hypoxia-induced lipid formation and inflammation through up-regulating HuR expression and inactivating AMPK pathways.Bioscience reports · 2021Article
- In search of the optimal management strategy for non-alcoholic fatty liver disease in type 2 diabetes patients.Journal of diabetes investigation · 2021Article
- Clinical evidence regarding factors linking metabolic abnormal obesity to pancreatic β-cell dysfunction.Journal of diabetes investigation · 2020Article
- Obesity, metabolic syndrome and bariatric surgery: A narrative review.Journal of diabetes investigation · 2020Review
- Circulating Wnt1-inducible signaling pathway protein-1 (WISP-1/CCN4) is a novel biomarker of adiposity in subjects with type 2 diabetes.Journal of cell communication and signaling · 2020Article
- Nonlinear relationship between serum uric acid and body mass index: a cross-sectional study of a general population in coastal China.Journal of translational medicine · 2019Article
- Peroxisomal regulation of redox homeostasis and adipocyte metabolism.Redox biology · 2019Review
- Nicotinic alpha-7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis.Journal of diabetes investigation · 2019Article
- Intermittent Hypoxia Up-RegulatesInternational journal of molecular sciences · 2019Article
- Effects of exercise training on markers of adipose tissue remodeling in patients with coronary artery disease and type 2 diabetes mellitus: sub study of the randomized controlled EXCADI trial.Diabetology & metabolic syndrome · 2019Article
- Exosome and Macrophage Crosstalk in Sleep-Disordered Breathing-Induced Metabolic Dysfunction.International journal of molecular sciences · 2018Review
- Molecular mechanism of obesity-induced 'metabolic' tissue remodeling.Journal of diabetes investigation · 2018Review
- Acupuncture on Obesity: Clinical Evidence and Possible Neuroendocrine Mechanisms.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury.Tzu chi medical journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic inflammation is a common molecular basis underlying a variety of chronic diseases. Accumulating evidence has also suggested that chronic inflammation contributes to the pathogenesis of obesity and diabetes, which have been considered as metabolic diseases. For the past several decades, there has been dramatic progress in understanding the underlying mechanism of adipose tissue dysfunction induced by obesity. Tissue remodeling is one of the histological features of chronic inflammation, in which stromal cells dramatically change in number and cell type. Indeed, adipose tissue remodeling is induced by various stromal cells, and results in the impairment of adipose tissue function, such as adipocytokine production and lipid storage, which leads to systemic metabolic disorder. In addition to adipose tissue, the liver is another example of obesity-induced tissue remodeling. In the present review, we discuss how obesity induces interstitial fibrosis in adipose tissue and the liver, particularly focusing on the role of macrophages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.