ArticleHuman brain mapping2018
Ventral striatal network connectivity reflects reward learning and behavior in patients with Parkinson's disease.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Imaging Cognitive Impairment and Impulse Control Disorders in Parkinson's Disease.Frontiers in neurology · 2021Pooled it
- The Effect of Dopaminergic Medication on Impulse Control and Compulsive Behaviour: A Translational Perspective.Basic & clinical pharmacology & toxicology · 2026Review
- Central Involvement in Pure Autonomic Failure: Insights from Neuromelanin-Sensitive Magnetic Resonance Imaging andMovement disorders : official journal of the Movement Disorder Society · 2025Article
- Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Neural network localization in Parkinson's disease with impulse control disorders.Frontiers in aging neuroscience · 2025Article
- Pilot study comparing effects of infrared neuromodulation and transcranial magnetic stimulation using magnetic resonance imaging.Frontiers in human neuroscience · 2025Article
- The Role of a Dopamine-Dependent Limbic-Motor Network in Sensory Motor Processing in Parkinson Disease.Journal of cognitive neuroscience · 2023Article
- Imaging the Limbic System in Parkinson's Disease-A Review of Limbic Pathology and Clinical Symptoms.Brain sciences · 2022Review
- Dopamine-induced changes to thalamic GABA concentration in impulsive Parkinson disease patients.NPJ Parkinson's disease · 2022Article
- DThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Symptoms of Medication Withdrawal in Parkinson's Disease: Considerations for Informed Consent in Patient-Oriented Research.Pharmaceutical medicine · 2021Article
- Functional Connectome in Parkinson's Disease and Parkinsonism.Current neurology and neuroscience reports · 2021Review
- Impulse Control Disorders in Parkinson's Disease: Epidemiology, Pathogenesis and Therapeutic Strategies.Frontiers in psychiatry · 2021Review
- Unmasking neurobiological commonalities between addictive disorders and impulse control disorders in Parkinson's disease.Brain imaging and behavior · 2020Review
- Self-reported rates of impulsivity in Parkinson's Disease.Annals of clinical and translational neurology · 2020Article
- Intrinsic Functional and Structural Brain Connectivity in Humans Predicts Individual Social Comparison Orientation.Frontiers in psychiatry · 2020Article
- Abnormalities of striatal morphology in gambling disorder and at-risk gambling.CNS spectrums · 2019Article
- Brain Imaging and Impulse Control Disorders in Parkinson's Disease.Current neurology and neuroscience reports · 2019Review
- Dopamine effects on frontal cortical blood flow and motor inhibition in Parkinson's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Impulse Control Disorders in Parkinson's Disease. A Brief and Comprehensive Review.Frontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
A subgroup of Parkinson's disease (PD) patients treated with dopaminergic therapy develop compulsive reward-driven behaviors, which can result in life-altering morbidity. The mesocorticolimbic dopamine network guides reward-motivated behavior; however, its role in this treatment-related behavioral phenotype is incompletely understood. Here, mesocorticolimbic network function in PD patients who develop impulsive and compulsive behaviors (ICB) in response to dopamine agonists was assessed using BOLD fMRI. The tested hypothesis was that network connectivity between the ventral striatum and the limbic cortex is elevated in patients with ICB and that reward-learning proficiency reflects the extent of mesocorticolimbic network connectivity. To evaluate this hypothesis, 3.0T BOLD-fMRI was applied to measure baseline functional connectivity on and off dopamine agonist therapy in age and sex-matched PD patients with (n = 19) or without (n = 18) ICB. An incentive-based task was administered to a subset of patients (n = 20) to quantify positively or negatively reinforced learning. Whole-brain voxelwise analyses and region-of-interest-based mixed linear effects modeling were performed. Elevated ventral striatal connectivity to the anterior cingulate gyrus (P = 0.013), orbitofrontal cortex (P = 0.034), insula (P = 0.044), putamen (P = 0.014), globus pallidus (P < 0.01), and thalamus (P < 0.01) was observed in patients with ICB. A strong trend for elevated amygdala-to-midbrain connectivity was found in ICB patients on dopamine agonist. Ventral striatum-to-subgenual cingulate connectivity correlated with reward learning (P < 0.01), but not with punishment-avoidance learning. These data indicate that PD-ICB patients have elevated network connectivity in the mesocorticolimbic network. Behaviorally, proficient reward-based learning is related to this enhanced limbic and ventral striatal connectivity. Hum Brain Mapp 39:509-521, 2018. © 2017 Wiley Periodicals, Inc.
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