ArticleJournal of magnetic resonance imaging : JMRI2018
Pulmonary ventilation imaging in asthma and cystic fibrosis using oxygen-enhanced 3D radial ultrashort echo time MRI.
Article in Journal of magnetic resonance imaging : JMRI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
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- Dynamic lung water MRI during exercise stress.Magnetic resonance in medicine · 2023Article
- Multi-parametric MRI for radiotherapy simulation.Medical physics · 2023Review
- Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.Annals of the American Thoracic Society · 2023Article
- Imaging Regional Airway Involvement of Asthma: Heterogeneity in Ventilation, Mucus Plugs and Remodeling.Advances in experimental medicine and biology · 2023Article
- Measuring short-term changes in specific ventilation using dynamic specific ventilation imaging.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Free-Breathing Phase-Resolved Oxygen-Enhanced Pulmonary MRI Based on 3D Stack-of-Stars UTE Sequence.Sensors (Basel, Switzerland) · 2022Article
- Self-gated 3D stack-of-spirals UTE pulmonary imaging at 0.55T.Magnetic resonance in medicine · 2022Article
- Practical protocol for lung magnetic resonance imaging and common clinical indications.Pediatric radiology · 2022Review
- Oxygen-enhanced functional lung imaging using a contemporary 0.55 T MRI system.NMR in biomedicine · 2021Article
- T2-weighted Lung Imaging Using a 0.55-T MRI System.Radiology. Cardiothoracic imaging · 2021Article
- Evaluation of pulmonary ventilation in COVID-19 patients using oxygen-enhanced three-dimensional ultrashort echo time MRI: a preliminary study.Clinical radiology · 2021Article
- Novel imaging techniques for cystic fibrosis lung disease.Pediatric pulmonology · 2021Review
- Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI.Frontiers in oncology · 2021Article
- Current state of the art MRI for the longitudinal assessment of cystic fibrosis.Journal of magnetic resonance imaging : JMRI · 2020Review
- [Assessment of lung impairment in patients with cystic fibrosis : Novel magnetic resonance imaging methods].Der Radiologe · 2020Review
- 2019 American Thoracic Society BEAR Cage Winning Proposal: Lung Imaging Using High-Performance Low-Field Magnetic Resonance Imaging.American journal of respiratory and critical care medicine · 2020Article
- Deep convolutional neural networks with multiplane consensus labeling for lung function quantification using UTE proton MRI.Journal of magnetic resonance imaging : JMRI · 2019Article
- SUSAN: segment unannotated image structure using adversarial network.Magnetic resonance in medicine · 2019Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundA previous study demonstrated the feasibility of using 3D radial ultrashort echo time (UTE) oxygen-enhanced MRI (UTE OE-MRI) for functional imaging of healthy human lungs. The repeatability of quantitative measures from UTE OE-MRI needs to be established prior to its application in clinical research. PURPOSE: To evaluate repeatability of obstructive patterns in asthma and cystic fibrosis (CF) with UTE OE-MRI with isotropic spatial resolution and full chest coverage. STUDY TYPE: Volunteer and patient repeatability. POPULATION: Eighteen human subjects (five asthma, six CF, and seven normal subjects). FIELD STRENGTH/SEQUENCE: Respiratory-gated free-breathing 3D radial UTE (80 μs) sequence at 1.5T. ASSESSMENT: Two 3D radial UTE volumes were acquired sequentially under normoxic and hyperoxic conditions. A subset of subjects underwent repeat acquisitions on either the same day or ≤15 days apart. Asthma and CF subjects also underwent spirometry. A workflow including deformable registration and retrospective lung density correction was used to compute 3D isotropic percent signal enhancement (PSE) maps. Median PSE (MPSE) and ventilation defect percent (VDP) of the lung were measured from the PSE map. STATISTICAL TESTS: The relations between MPSE, VDP, and spirometric measures were assessed using Spearman correlations. The test-retest repeatability was evaluated using Bland-Altman analysis and intraclass correlation coefficients (ICC).
resultsVentilation measures in normal subjects (MPSE = 8.0%, VDP = 3.3%) were significantly different from those in asthma (MPSE = 6.0%, P = 0.042; VDP = 21.7%, P = 0.018) and CF group (MPSE = 4.5%, P = 0.0006; VDP = 27.2%, P = 0.002). MPSE correlated significantly with forced expiratory lung volume in 1 second percent predicted (ρ = 0.72, P = 0.017). The ICC of the test-retest VDP and MPSE were both ≥0.90. In all subject groups, an anterior/posterior gradient was observed with higher MPSE and lower VDP in the posterior compared to anterior regions (P ≤ 0.0021 for all comparisons). DATA
conclusion3D radial UTE OE-MRI supports quantitative differentiation of diseased vs. healthy lungs using either whole lung VDP or MPSE with excellent test-retest repeatability. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:1287-1297.
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