Evidence map›Paper›PMID 29086437›Full record

ArticleMagnetic resonance in medicine2018

Fast quantitative parameter maps without fitting: Integration yields accurate mono-exponential signal decay rates.

Ruitian Song, Ralf B Loeffler, Joseph L Holtrop, M Beth McCarville, Jane S Hankins, Claudia M Hillenbrand

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ruitian SongDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Ralf B LoefflerDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Joseph L HoltropDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
M Beth McCarvilleDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jane S HankinsDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Claudia M HillenbrandDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
St. Jude Children's Research Hospital · US

Funding

Massive Iron Deposit Assessment (MIDAS)R01DK088988 · NIDDK · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HANKINS, JANE SILVA, HILLENBRAND, CLAUDIA M · 2010 to 2013
$1.5M
NIDDK NIH HHS R01 DK088988
6 · The paper itself

Abstract

purposeTo develop a computationally fast and accurate algorithm for mono-exponential signal modelling and validate the new technique in the context of R2* mapping for iron overload assessment.

methodsAn algorithm is introduced that directly calculates R2* values from a series of images based on integration of the mono-exponential signal decay curve. The algorithm is fast, because fitting is avoided and only arithmetic computations without iterations are applied. Precision and accuracy of the method is determined in comparison to the conventional log-linear (LL), nonlinear least-squares-based Levenberg-Marquardt (NLM), and squared nonlinear Levenberg-Marquardt (SQNLM) methods, which rely on iterative curve fitting.

resultsIn simulations, the signal integration based method consistently had the same or better accuracy than the LL, NLM, and SQNLM algorithms for R2* values ranging from 50 s

conclusionsThe fast signal integration method accurately calculates R2* maps. It has the potential to replace conventional, mono-exponential fitting methods for quantitative MRI such as R2* parameter mapping. Magn Reson Med 79:2978-2985, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Indexed as

Magnetic Resonance ImagingSignal Processing, Computer-AssistedAdolescentAdultAlgorithmsComputer SimulationFemaleFourier AnalysisHumansIron OverloadLinear ModelsMaleModels, StatisticalPhantoms, ImagingReproducibility of ResultsSignal-To-Noise Ratioapparent transverse relaxation ratefast R2*/ T2* mappinggradient echoes (GRE)iron overloadrelaxivity fitting

Identifiers

PMID29086437
PMCPMC6225998
OpenAlexW2766462591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.