Evidence map›Paper›PMID 29086386›Full record

SynthesisJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019

Meta-analysis of 18F-FDG PET/CT in the diagnosis of infective endocarditis.

Maryam Mahmood, Ayse Tuba Kendi, Saira Ajmal, Saira Farid, John C O'Horo, Panithaya Chareonthaitawee, Larry M Baddour, M Rizwan Sohail

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 5 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 5 syntheses or guidelines pooled it, 206 citations in OpenAlex.

  1. Guideline
  2. EANM/SNMMI guideline/procedure standard for [European journal of nuclear medicine and molecular imaging · 2025
    Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Prevalence of Persistent Cardiovascular and Pulmonary Abnormalities on PET/MRI and DECT Imaging in Long COVID Patients.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  12. Review
  13. Diagnostics (Basel, Switzerland) · 2025
    Review
  14. Innovations in Imaging:Current cardiology reports · 2024
    Review
  15. Article
  16. Review
  17. The Diagnostic Yield of [Diagnostics (Basel, Switzerland) · 2024
    Article
  18. Contemporary surgical management of infective endocarditis of the aortic root.Indian journal of thoracic and cardiovascular surgery · 2024
    Review
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maryam MahmoodDivision of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN, 55905, USA. mahmood.maryam@mayo.edu.
Ayse Tuba KendiDivision of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Saira AjmalDivision of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN, 55905, USA.
Saira FaridDivision of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN, 55905, USA.
John C O'HoroDivision of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN, 55905, USA.
Panithaya ChareonthaitaweeDepartment of Cardiovascular Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Larry M BaddourDivision of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN, 55905, USA.
M Rizwan SohailDivision of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN, 55905, USA.
Mayo Clinic · USMayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe current diagnosis of infective endocarditis (IE) is based on the modified Duke criteria, which has approximately 80% sensitivity for the diagnosis of native valve endocarditis (NVE), with lower sensitivity for the diagnosis of prosthetic valve endocarditis (PVE) and culture-negative endocarditis. There is preliminary evidence that

methodsPubMed, Embase, Cochrane library, CINAHL, Web of Knowledge, and www.clinicaltrials.gov were searched from January 1990 to April 2017 for studies evaluating the accuracy of PET/CT for the evaluation of possible IE.

resultsWe identified 13 studies involving 537 patients that were included in the meta-analysis. The pooled sensitivity of PET/CT for diagnosis of IE was 76.8% (95% CI 71.8-81.4%; Q = 39.9, P < 0.01; I

conclusionPET/CT is a useful adjunctive diagnostic tool in the evaluation of diagnostically challenging cases of IE, particularly in prosthetic valve endocarditis. It also has the potential to detect clinically relevant extracardiac foci of infection, malignancy, and other sources of inflammation leading to more appropriate treatment regimens and surgical intervention.

Indexed as

Fluorodeoxyglucose F18Positron Emission Tomography Computed TomographyRadiopharmaceuticalsEndocarditisHumansSensitivity and SpecificityFluorodeoxyglucose F18RadiopharmaceuticalsEndocarditisimaginginfectionmeta-analysisPET

Identifiers

PMID29086386
OpenAlexW2766525355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.