Evidence map›Paper›PMID 29086334›Full record

ArticleDigestive diseases and sciences2017

Response to TNF-α Is Increasing Along with the Progression in Barrett's Esophagus.

Olga Chemnitzer, Katharina Götzel, Luisa Maurer, Arne Dietrich, Uwe Eichfeld, Orestis Lyros, Boris Jansen-Winkeln, Albrecht Hoffmeister, Ines Gockel, René Thieme

Abstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Esophageal cancer: from pathogenesis to precision therapies.Signal transduction and targeted therapy · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Cytokine Interaction With Cancer-Associated Fibroblasts in Esophageal Cancer.Cancer control : journal of the Moffitt Cancer Center
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Olga ChemnitzerDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Katharina GötzelDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Luisa MaurerDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Arne DietrichDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Uwe EichfeldDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Orestis LyrosDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Boris Jansen-WinkelnDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Albrecht HoffmeisterDepartment of Gastroenterology and Rheumatology, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
Ines GockelDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.
René ThiemeDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany. rene.thieme@medizin.uni-leipzig.de.ORCID 0000-0002-0537-3979
University Hospital Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsBarrett's esophagus, a metaplasia resulting from a long-standing reflux disease, and its progression to esophageal adenocarcinoma (EAC) are characterized by activation of pro-inflammatory pathways, induced by cytokines.

methodsAn in vitro cell culture system representing the sequence of squamous epithelium (EPC1 and EPC2), Barrett's metaplasia (CP-A), dysplasia (CP-B) to EAC (OE33 and OE19) was used to investigate TNF-α-mediated induction of interleukin-8 (IL-8).

resultsIL-6 and IL-8 expressions are increasing with the progression of Barrett's esophagus, with the highest expression of both cytokines in the dysplastic cell line CP-B. IL-8 expression in EAC cells was approx. 4.4-fold (OE33) and eightfold (OE19) higher in EAC cells than in squamous epithelium cells (EPC1 and EPC2). The pro-inflammatory cytokine TNF-α increased IL-8 expression in a time-, concentration-, and stage-specific manner. Furthermore, TNF-α changed the EMT marker profile in OE33 cells by decreasing the epithelial marker E-cadherin and increasing the mesenchymal marker vimentin. The anti-inflammatory compound curcumin was able to repress proliferation and to activate apoptosis in both EAC cell lines.

conclusionThe increased basal expression levels of IL-8 with the progression of Barrett's esophagus constrain NFκB activation and its contribution in the manifestation of Barrett's esophagus. An anti-inflammatory compound, such as curcumin, could create an anti-inflammatory microenvironment and thus potentially support an increase chemosensitivity in EAC cells.

Indexed as

AdenocarcinomaAnti-Inflammatory Agents, Non-SteroidalBarrett EsophagusCell LineCurcuminDisease ProgressionDrug Evaluation, PreclinicalEpithelial-Mesenchymal TransitionEsophageal NeoplasmsHumansInterleukin-6Interleukin-8Tumor Necrosis Factor-alphaVimentinAnti-Inflammatory Agents, Non-SteroidalCurcuminIL6 protein, humanInterleukin-6Interleukin-8Tumor Necrosis Factor-alphaVimentinBarrett’s esophagusEMTEsophageal adenocarcinomaInflammationTNF-α

Identifiers

PMID29086334
OpenAlexW2766519798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.