Evidence map›Paper›PMID 29086160›Full record

ArticleThe journal of headache and pain2017

Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC).

Simona Sacco, Gabriele S Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E Anne MacGregor, Antoinette MaassenVanDenBrink and 6 more

Erratum issuedOpen access · goldAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 64 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 2 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 180 citations in OpenAlex.

  1. Profiling cerebrovascular function in migraine: A systematic review and meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 10 countries.

Simona SaccoDepartment of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy. simona.sacco@univaq.it.ORCID http://orcid.org/0000-0003-0651-1939
Gabriele S Merki-FeldDepartment of Gynecology, Clinic for Reproductive Endocrinology, University Hospital, Zürich, Switzerland.
Karen Lehrmann ÆgidiusDepartment of Neurology, Bispebjerg Hospital and University of Copenhagen, Copenhagen, Denmark.
Johannes BitzerDepartment of Obstetrics and Gynecology, University Hospital of Basel, Basel, Switzerland.
Marianne CanonicoUniversité Paris-Saclay, University Paris-Sud, UVSQ, CESP, Inserm UMRS1018, Orsay, France.
Tobias KurthInstitute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Christian LamplHeadache Medical Center Seilerstaette Linz, Linz, Austria.
Øjvind LidegaardDepartment of Obstetrics & Gynaecology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
E Anne MacGregorCentre for Neuroscience & Trauma, BICMS, Barts and the London School of Medicine and Dentistry, London, UK.
Antoinette MaassenVanDenBrinkDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Dimos-Dimitrios MitsikostasDepartment of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Rossella Elena NappiResearch Centre for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS S. Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
George NtaiosDepartment of Medicine, University of Thessaly, Larissa, Greece.
Per Morten SandsetDepartment of Haematology, Oslo University Hospital and University of Oslo, Oslo, Norway.
Paolo MartellettiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)
University of Copenhagen · DKInserm · FRNational and Kapodistrian University of Athens · GROslo University Hospital · NOUniversity of L'Aquila · ITCTO Andrea Alesini · ITKepler Universitätsklinikum · ATSt Bartholomew's Hospital · GBUniversity of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migraineurs is magnified by the use of hormonal contraceptives. As migraine prevalence is high in women of reproductive age, it is common to face the issue of migraine and hormonal contraceptive use in clinical practice. In this document, we systematically reviewed data about the association between migraine, ischemic stroke and hormonal contraceptive use. Thereafter a consensus procedure among international experts was done to develop statements to support clinical decision making, in terms of cardiovascular safety, for prescription of hormonal contraceptives to women with migraine. Overall, quality of current evidence regarding the risk of ischemic stroke in migraineurs associated with the use of hormonal contraceptives is low. Available data suggest that combined hormonal contraceptive may further increase the risk of ischemic stroke in those who have migraine, specifically migraine with aura. Thus, our current statements privilege safety and provide several suggestions to try to avoid possible risks. As the quality of available data is poor further research is needed on this topic to increase safe use of hormonal contraceptives in women with migraine.

Indexed as

ConsensusBrain IschemiaContraceptives, Oral, CombinedContraceptives, Oral, HormonalFemaleHumansMigraine DisordersMigraine with AuraReproductive HealthRiskRisk FactorsStrokeContraceptives, Oral, CombinedContraceptives, Oral, HormonalAuraContraceptionHeadacheHormonal contraceptivesMigraineStroke

Identifiers

PMID29086160
PMCPMC5662520
OpenAlexW2765134567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.