ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2018
Hydrocephalus associated to congenital Zika syndrome: does shunting improve clinical features?
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review.F1000Research · 2019Pooled it
- Virus as Teratogenic Agents.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Zika virus infection histories in brain development.Disease models & mechanisms · 2023Review
- A neural stem cell paradigm of pediatric hydrocephalus.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Complex Neuroimmune Involvement in Neurodevelopment: A Mini-Review.Journal of inflammation research · 2023Review
- Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities.Current neurology and neuroscience reports · 2020Review
- The Spectrum of Developmental Disability with Zika Exposure: What Is Known, What Is Unknown, and Implications for Clinicians.Journal of developmental and behavioral pediatrics : JDBP · 2019Review
- Zika virus and the nonmicrocephalic fetus: why we should still worry.American journal of obstetrics and gynecology · 2019Review
- Reply to the letter by Joob and Wiwanitkit regarding our article on congenital Zika syndrome and hydrocephalus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Hydrocephalus associated to congenital Zika syndrome and shunting.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- The congenital Zika virus infection: still a puzzle.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCongenital Zika syndrome (CZS) is a new entity with little information about its course and natural history. It is known that prenatal infection by Zika virus is associated to disrupted nervous system development, leading to typical neurological disabilities and deformities. Some children present progressive ventriculomegaly and hydrocephalus associated to aggravation of seizures and neurological impairment. The aim of this study is to evaluate the development of hydrocephalus and the impact of ventriculoperitoneal shunt insertion in the clinical condition of these children.
methodsData was obtained from chart review, direct interviews with patients' parents, direct neurological examination, and analysis of pre- and postoperative neuroimages.
resultsA group of 115 patients had CZS diagnosis from November 2015 to July 2017. Among them, 21 (18.3%) patients had ventricular enlargement noted on follow-up CT scans. Six children (28.6%) underwent a ventriculoperitoneal shunt and all had some improvement after surgery concerning either waking time during the day and better interaction. Overall improvement was also noted in seizures. Spasticity decrease and more cervical control were also achieved. In two out of six cases, a slight increase in parenchymal length could be noted on the CT scans.
conclusionThis series points out the possibility of hypertensive hydrocephalus development in CZS patients. Affected children may benefit from VP shunt insertion. These findings suggest a dual pathology association: fetal brain disruption and primary cortical malformation by the virus itself and hypertensive hydrocephalus. This is already seen in some cases of congenital rubella, toxoplasmosis, or cytomegalovirus-associated hydrocephalus.
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