ReviewMedical oncology (Northwood, London, England)2017
Primary tumor resection in stage IV unresectable colorectal cancer: what has changed?
Review in Medical oncology (Northwood, London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bevacizumab improves survival in metastatic colorectal cancer patients with primary tumor resection: A meta-analysis.Scientific reports · 2019Pooled it
- Patterns of care in patients with asymptomatic stage IV colon cancer: A population-based analysis.Surgery · 2025Article
- A predictive model to identify optimal candidates for surgery among patients with metastatic colorectal cancer.Frontiers in oncology · 2025Article
- Oxidative Phosphorylation as a Predictive Biomarker of Oxaliplatin Response in Colorectal Cancer.Biomolecules · 2024Article
- Review
- Primary tumor resection in colorectal cancer patients with unresectable distant metastases: a minireview.Frontiers in oncology · 2023Review
- InoperableMolecular and clinical oncology · 2022Article
- Impact of postoperative complications after primary tumor resection on survival in patients with incurable stage IV colorectal cancer: A multicenter retrospective cohort study.Annals of gastroenterological surgery · 2021Article
- Article
- Individualized prediction of survival benefit from primary tumor resection for patients with unresectable metastatic colorectal cancer.World journal of surgical oncology · 2020Article
- Does primary tumor resection contribute to overall survival in unresectable synchronous metastatic colorectal cancer?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Article
- Surgery of primary tumor improves the survival of newly diagnosed metastatic melanoma: a population-based, propensity-matched study.Cancer management and research · 2019Article
- Current status of enhanced recovery after surgery (ERAS) protocol in gastrointestinal surgery.Medical oncology (Northwood, London, England) · 2018Review
- Novel regimens and treatment strategies in neoadjuvant therapy for colorectal cancer: A systematic review.International journal of health sciencesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most current guidelines do not recommend primary tumor resection in stage IV unresectable colorectal cancer. Rapid chemotherapy development over the last decade has substantially changed the decision making. However, results of recently published trials and meta-analyses suggest that primary tumor resection may in fact be beneficial, principally in terms of prolonged survival. Additional factors, such as use of minimally invasive approach or protocols of enhanced recovery after surgery, affect clinical outcomes as well, but are often neglected when discussing the state of the art in this area. There are still no randomized studies determining the legitimacy of upfront surgery in asymptomatic patients. Also, quality of life also plays an important role in choosing appropriate treatment. Having said that, there is no data that would prove whether primary tumor resection has an advantage on that issue. With all the uncertainty, currently decision making in unresectable stage IV colorectal cancer is primarily up to clinicians' knowledge, common sense and patients' preferences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.