ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Stability of Cortical Thinning in Persons at Increased Familial Risk for Major Depressive Disorder Across 8 Years.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Relationship Between Family History of Depression and Brain Structure and Function: A Systematic Review of Large Cohorts.Biological psychiatry · 2026Pooled it
- Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies.Developmental cognitive neuroscience · 2019Pooled it
- Integrating brain imaging features and genomic profiles for the subtyping of major depression.Psychological medicine · 2025Article
- Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children.Journal of integrative neuroscience · 2024Article
- Big or Little Data for Magnetic Resonance Imaging Research in Psychiatry?Biological psychiatry · 2023Article
- Article
- Age-dependent effects of schizophrenia genetic risk on cortical thickness and cortical surface area: Evaluating evidence for neurodevelopmental and neurodegenerative models of schizophrenia.Journal of psychopathology and clinical science · 2022Article
- Associations Between Parental Mood and Anxiety Psychopathology and Offspring Brain Structure: A Scoping Review.Clinical child and family psychology review · 2022Article
- Altruism and "love of neighbor" offer neuroanatomical protection against depression.Psychiatry research. Neuroimaging · 2021Article
- Dissociating default mode network resting state markers of suicide from familial risk factors for depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Neuroimaging markers of adolescent depression in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study.Journal of affective disorders · 2021Article
- Intergenerational psychiatry: a new look at a powerful perspective.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Increased ASL-CBF in the right amygdala predicts the first onset of depression in healthy young first-degree relatives of patients with major depression.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Depression Severity Over 27 Months in Adolescent Girls Is Predicted by Stress-Linked Cortical Morphology.Biological psychiatry · 2019Article
- A diffusion tensor imaging study of brain microstructural changes related to religion and spirituality in families at high risk for depression.Brain and behavior · 2019Article
- Family Risk for Depression and Prioritization of Religion or Spirituality: Early Neurophysiological Modulations of Motivated Attention.Frontiers in human neuroscience · 2019Article
- Temporal stability of posterior EEG alpha over twelve years.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Article
- Risks for Major Depression: Searching for Stable Traits.Biological psychiatry · 2018Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundA biological marker of vulnerability should precede onset of illness and be independent of disease course. We previously reported that cortical thinning may serve as a potential biomarker for risk for familial depression. We now test stability of the cortical thinning across 8 years, and whether thinning mediates associations between familial risk and depressive traits.
methodParticipants were from a 3-generation family study of depression, where 2nd and 3rd generation offspring were characterized as being at high- or low-risk for depression based on the presence/absence of major depression in the 1st generation. The analysis includes 82 offspring with anatomical MRI scans across two assessment waves, 7.8 (S.D.1.3, range: 5.2-10.9) years apart.
resultsHigh-risk offspring had thinner bilateral superior and middle frontal gyri, and left inferior parietal lobule, at both time-points. High intra-subject correlation (0.60<r<0.91) and intra-class correlation (0.72-0.78) of thickness measures across time points was detected within the above regions; rank order by effect size and region was also preserved across time. The thinning was stable despite changes in scanning platform (Siemens Sonata vs. GE Signa), field-strength (1.5 vs. 3T), and participant age and clinical course. Thinning at the first time-point predicted anger and hostility at the second, and mediated the relationship between familial risk and these traits.
conclusionThe study provides evidence for cortical thinning as a stable biomarker for familial vulnerability for depressive illness, which supports the ability to detect persistent and clinically relevant anatomical findings irrespective of MRI platform.
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