ArticleeNeuro
Functional Neuroplasticity in the Nucleus Tractus Solitarius and Increased Risk of Sudden Death in Mice with Acquired Temporal Lobe Epilepsy.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The solitary nucleus connectivity to key autonomic regions in humans.The European journal of neuroscience · 2022Pooled it
- Electroacupuncture-based vagal stimulation attenuates epileptic seizures through a body-brain circuit.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Astrocytes at the interface of peri-ictal breathing dysfunction and SUDEP.Frontiers in network physiology · 2026Review
- The Crucial Interplay Between the Lungs, Brain, and Heart to Understand Epilepsy-Linked SUDEP: A Literature Review.Brain sciences · 2025Review
- Cardiogenic and chronobiological mechanisms in seizure-induced sinus arrhythmias.PLoS computational biology · 2025Article
- Article
- Sudden Unexpected Death in Epilepsy: Central Respiratory Chemoreception.International journal of molecular sciences · 2025Review
- Challenges and future directions of SUDEP models.Lab animal · 2024Review
- Neuronal plasticity contributes to postictal death.Progress in neurobiology · 2023Article
- Inhibitory Neurons in Nucleus Tractus Solitarius Are Involved in Decrease of Heart Rate Variability and Development of Depression-Like Behaviors in Temporal Lobe Epilepsy.The international journal of neuropsychopharmacology · 2023Article
- Audiogenic epileptic DBA/2 mice strain as a model of genetic reflex seizures and SUDEP.Frontiers in neurology · 2023Review
- Adenosine-AFrontiers in pharmacology · 2022Article
- Autonomic dysfunction in epilepsy mouse models with implications for SUDEP research.Frontiers in neurology · 2022Review
- Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP.Epilepsy currents · 2021Article
- Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy.JCI insight · 2020Article
- Apnea Associated with Brainstem Seizures inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Altered A-type potassium channel function in the nucleus tractus solitarii in acquired temporal lobe epilepsy.Journal of neurophysiology · 2019Article
- Article
- Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models.Epilepsy currentsArticle
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in individuals with refractory acquired epilepsy. Cardiorespiratory failure is the most likely cause in most cases, and central autonomic dysfunction has been implicated as a contributing factor to SUDEP. Neurons of the nucleus tractus solitarius (NTS) in the brainstem vagal complex receive and integrate vagally mediated information regarding cardiorespiratory and other autonomic functions, and GABAergic inhibitory NTS neurons play an essential role in modulating autonomic output. We assessed the activity of GABAergic NTS neurons as a function of epilepsy development in the pilocarpine-induced status epilepticus (SE) model of temporal lobe epilepsy (TLE). Compared with age-matched controls, mice that survived SE had significantly lower survival rates by 150 d post-SE. GABAergic NTS neurons from mice that survived SE displayed a glutamate-dependent increase in spontaneous action potential firing rate by 12 wks post-SE. Increased spontaneous EPSC frequency was also detected, but vagal afferent synaptic release properties were unaltered, suggesting that an increase in glutamate release from central neurons developed in the NTS after SE. Our results indicate that long-term changes in glutamate release and activity of GABAergic neurons emerge in the NTS in association with epileptogenesis. These changes might contribute to increased risk of cardiorespiratory dysfunction and sudden death in this model of TLE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.