ArticleTurkish journal of obstetrics and gynecology2017
Can we predict severity of intrahepatic cholestasis of pregnancy using inflammatory markers?
Article in Turkish journal of obstetrics and gynecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Red blood cell distribution width in pregnancy: a systematic review.Biochemia medica · 2018Pooled it
- Maternal and neonatal systemic inflammatory indices and perinatal outcomes in methamphetamine-exposed pregnancies.BMC pregnancy and childbirth · 2026Article
- The Role of the Delta Neutrophil Index in Determining the Severity of Intrahepatic Cholestasis of Pregnancy.Saudi medical journal · 2026Article
- Inflammatory hematologic indices in intrahepatic cholestasis of pregnancy: a retrospective case-control study focusing on the aggregate index of systemic inflammation.BMC pregnancy and childbirth · 2026Article
- Aortic Elastic Properties and Albumin-Based Inflammatory Indices in Dyspneic Third-Trimester Pregnant Women: A Prospective Observational Study.Biomedicines · 2026Article
- Predictive value of inflammatory indices for disease severity and perinatal outcomes in intrahepatic cholestasis of pregnancy.BMC pediatrics · 2025Article
- Systemic immune-inflammatory index and platelet-to-lymphocyte ratio in intrahepatic cholestasis of pregnancy.Saudi medical journal · 2024Article
- Analysis of changes in platelet parameters and inflammatory markers in intrahepatic cholestasis of pregnancy before disease development.American journal of translational research · 2024Article
- Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications.BMC public health · 2023Article
- Clinical value of mean platelet volume in predicting and diagnosing pre-eclampsia: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Investigation of red blood cell and platelet indices in adult dogs suffered from myxomatous mitral valve disease with and without pulmonary hypertension.Frontiers in veterinary science · 2023Article
- Intrahepatic Cholestasis of Pregnancy Is Associated with Reduced Nitric Oxide Synthase (iNOS) in Plasma and Placentas: A Pilot Study.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Association Between Complete Blood Count Components and Intrahepatic Cholestasis of Pregnancy.Cureus · 2020Article
- Evaluation of first-trimester neutrophil-lymphocyte ratio and platelet-lymphocyte ratio values in pregnancies complicated by intrauterine growth retardation.Turkish journal of obstetrics and gynecology · 2020Article
- Can mean platelet volume IndIcateActa clinica Croatica · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association of inflammatory markers with severity of intrahepatic cholestasis of pregnancy (ICP). MATERIALS AND
methodsThis retrospective case-control study was conducted with 229 pregnant women, 84 with ICP, and 145 age-matched healthy pregnant women. Patients were categorized as mild ICP (<40 µmol/L) and severe ICP (≥40 µmol/L) with regard to serum bile acids. Inflammatory markers (neutrophil-to-lymphocyte ratio (NLR), platelet-to- lymphocyte ratio (PLR) and mean platelet volume (MPV), and red blood cell distribution width (RDW) were compared between the groups.
resultsPatients with ICP had significantly decreased RDW and increased white blood cell counts (WBC), MPV and PLR, but no significant changes in NLR. The comparison of mild and severe cases with regard to NLR, PLR, WBC, and RDW was similar (p>0.05). MPV levels were significantly increased in severe group (p<0.05).
conclusionWBC, MPV, and PLR were the inflammatory markers significantly increased, and RDW was signifantly reduced in ICP. MPV was the marker that significantly increased with the severity of disease. The use of inflammatory markers in the assessment of perinatal outcomes needs further studies.
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