ArticleIranian journal of basic medical sciences2017
Protective effect of thymoquinone, the active constituent of
Article in Iranian journal of basic medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- Effects of pirfenidone and fisetin on apoptosis and oxidative stress mechanisms in heart tissue of bleomycin-induced pulmonary fibrosis.Journal of molecular histology · 2026Article
- Protective effect of thymoquinone against acrylamide-induced hepatotoxicity in the rat: role of MAPK and apoptosis pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Bisphenol A-Induced Vascular Endothelial Dysfunction: Protective Effects ofFood science & nutrition · 2025Article
- Synergistic Anti-Cancer Effects of Curcumin and Thymoquinone Against Melanoma.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Thymoquinone attenuates olanzapine-induced metabolic disorders in rats.Molecular biology reports · 2023Article
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- Effect of NaturalToxics · 2022Article
- Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption.Iranian journal of basic medical sciences · 2021Article
- Foliar application of seed water extract of Nigella sativa improved maize growth in cadmium-contaminated soil.PloS one · 2021Article
- Onion (Iranian journal of pharmaceutical research : IJPR · 2021Review
- Review
- Role of Oxidative Stress, MAPKinase and Apoptosis Pathways in the Protective Effects of Thymoquinone Against Acrylamide-Induced Central Nervous System Toxicity in Rat.Neurochemical research · 2020Article
- Effect of crocin, an active saffron constituent, on ethanol toxicity in the rat: histopathological and biochemical studies.Iranian journal of basic medical sciences · 2020Article
- Alcohol Consumption Can be a "Double-Edged Sword" for Chronic Kidney Disease Patients.Medical science monitor : international medical journal of experimental and clinical research · 2019Review
- Neuroprotective Effects of Thymoquinone in Acrylamide-Induced Peripheral Nervous System Toxicity Through MAPKinase and Apoptosis Pathways in Rat.Neurochemical research · 2019Article
- Thymoquinone, an Active Constituent of Black Seed Attenuates CCl4 Induced Liver Injury in Mice via Modulation of Antioxidant Enzymes, PTEN, P53 and VEGF Protein.Open access Macedonian journal of medical sciences · 2019Article
- A glance at black cumin (Iranian journal of basic medical sciences · 2018Review
- Article
- Amelioration of the Protein Expression of Cox2, NFDose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesLong term consumption of ethanol may induce damage to many organs. Ethanol induces its noxious effects through reactive oxygen species production, and lipid peroxidation and apoptosis induction in different tissues and cell types. Previous experiments have indicated the antioxidant characteristics of thymoquinone, the active constituent of MATERIALS AND
methodsExperiments were performed on six groups. Each group consisted of six animals, including control group (saline, gavage), ethanol-receiving group (3 g/kg/day, gavage), thymoquinone (2.5, 5, 10 mg/Kg/day, intraperitoneally (IP)) plus ethanol and thymoquinone (10 mg/Kg/day, IP) groups. Treatments were carried out in four weeks.
resultsThymoquinone reduced the ethanol-induced increase in the lipid peroxidation and severity of histopathological alteration in liver and kidney tissues. In addition it improved the levels of proinflammatory cytokines in liver tissue. Furthermore, thymoquinone corrected the liver enzymes level including alanine transaminase, aspartate transaminase and alkaline phosphatase in serum and glutathione content in liver and kidney tissues. Other experiments such as Western blot analysis and quantitative real-time RT-PCR revealed that thymoquinone suppressed the expression of Bax/Bcl-2 ratio (both protein and mRNA level), and caspases activation pursuant to ethanol toxicity.
conclusionThis study indicates that thymoquinone may have preventive effects against ethanol toxicity in the liver and kidney tissue through reduction in lipid peroxidation and inflammation, and also interrupting apoptosis.
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