ArticleIranian journal of basic medical sciences2017
Rapamycin protects testes against germ cell apoptosis and oxidative stress induced by testicular ischemia-reperfusion.
Article in Iranian journal of basic medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Metformin mitigates oxidative stress and prevents apoptosis by modulating the Nrf2/HO-1 signaling pathway in a rat model of testicular ischemia/reperfusion.Iranian journal of basic medical sciences · 2026Article
- Thymol alleviates silica dioxide nanoparticle-induced reproductive performance toxicity via antioxidant and anti-inflammatory mechanisms in male rats.Scientific reports · 2025Article
- Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models.Heliyon · 2024Review
- Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following testicular ischemia/reperfusion in rats: a comparative study.BMC pharmacology & toxicology · 2022Article
- Protective effect of osthole on testicular ischemia/reperfusion injury in rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Administration of Dexmedetomidine Does Not Produce Long-Term Protective Effect on Testicular Damage Post Testicular Ischemia-Reperfusion Injury.Drug design, development and therapy · 2021Article
- Short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Protective effect of hypothermia and vitamin E on spermatogenic function after reduction of testicular torsion in rats.Experimental and therapeutic medicine · 2020Article
- Protective effect of dipeptidyl peptidase-4 inhibitors in testicular torsion/detorsion in rats: a possible role of HIF-1α and nitric oxide.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Protective effects of orally administered thymol against titanium dioxide nanoparticle-induced testicular damage.Environmental science and pollution research international · 2020Article
- Rapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In Vitro.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Pioglitazone abrogates testicular damage induced by testicular torsion/detorsion in rats.Iranian journal of basic medical sciences · 2019Article
- Carvacrol treatment opens Kir6.2 ATP-dependent potassium channels and prevents apoptosis on rat testis following ischemia-reperfusion injury model.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury. MATERIALS AND
methodsSeventy-two adult male Wistar rats were divided into six groups: control (group1), sham-operated (Group2), T/D + DMSO as vehicle group (group3), and groups 4-6; respectively received 0.5, 1, and 1.5 mgkg
resultsTesticular T/D caused increases in the apoptosis, malondialdehyde (MDA), and caspase-3 levels and decreases in the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in ipsilateral testis (
conclusionRapamycin administration during testicular torsion decreased ischemia/reperfusion (I/R) cellular damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.