ArticleOncology letters2017
Upregulation of proline rich 11 is an independent unfavorable prognostic factor for survival of tongue squamous cell carcinoma patients.
Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- PRR11 in Malignancies: Biological Activities and Targeted Therapies.Biomolecules · 2022Review
- Proline-rich protein 11 overexpression is associated with a more aggressive phenotype and poor overall survival in ovarian cancer patients.World journal of surgical oncology · 2020Article
- Ultrasonic irradiation and SonoVue microbubbles-mediated RNA interference targeting PRR11 inhibits breast cancer cells proliferation and metastasis, but promotes apoptosis.Bioscience reports · 2020Article
- The oncogenic potential of PRR11 gene in Tongue Squamous Cell Carcinoma cells.Journal of Cancer · 2019Article
- Screening for proline‑rich protein 11 gene expression in cervical cancer: Use as a novel diagnostic biomarker and poor prognostic factor.Medicine internationalArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proline rich 11 (PRR11) serves an important role in the development and progression of a number of types of human cancer. However, the clinical role of PRR11 in tongue squamous cell carcinoma (TSCC) remains unknown. The present study aimed to investigate the expression and clinicopathological significance of PRR11 in TSCC. The Cancer Genome Atlas analysis demonstrated that the upregulation of PRR11 in TSCC correlated with poor prognosis. The data of the present study revealed that PRR11 mRNA and protein expression was markedly upregulated in human TSCC tissues. Immunohistochemistry on 72 archived paraffin-embedded TSCC specimens suggested that high levels of PRR11 expression were significantly associated with clinical stage (P<0.001), T classification (P=0.009), N classification (P=0.017) and vital status (P=0.010). In addition, patients with TSCC with higher PRR11 expression exhibited substantially shorter survival times compared with patients with lower PRR11 expression (P<0.001). Univariate and multivariate analyses indicated that PRR11 upregulation may be an independent prognostic factor for patients with TSCC (P=0.001). Taken together, and to the best of our knowledge, the results of the present study demonstrated for the first time that PRR11 is involved in the development and progression of TSCC, and may serve as a useful prognostic marker and an effective target for treating TSCC.
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