Evidence map›Paper›PMID 29085299›Full record

ArticleFrontiers in physiology2017

Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles.

Dominic G Whittaker, Haibo Ni, Alan P Benson, Jules C Hancox, Henggui Zhang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  5. Article
  6. Frontiers in physiology · 2022
    Article
  7. Biochemistry and biophysics reports · 2021
    Article
  8. Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation.International journal of molecular sciences · 2021
    Review
  9. Modelling sudden cardiac death risks factors in patients with coronavirus disease of 2019: the hydroxychloroquine and azithromycin case.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021
    Article
  10. Article
  11. Article
  12. In Silico Assessment of Class I Antiarrhythmic Drug Effects onInternational journal of molecular sciences · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Frontiers in physiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Dominic G WhittakerBiological Physics Group, School of Physics and Astronomy, University of Manchester, Manchester, United Kingdom.
Haibo NiBiological Physics Group, School of Physics and Astronomy, University of Manchester, Manchester, United Kingdom.
Alan P BensonSchool of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
Jules C HancoxBiological Physics Group, School of Physics and Astronomy, University of Manchester, Manchester, United Kingdom.
Henggui ZhangBiological Physics Group, School of Physics and Astronomy, University of Manchester, Manchester, United Kingdom.
University of Manchester · GBHarbin Institute of Technology · CNUniversity of Bristol · GBUniversity of Leeds · GB

Funding

British Heart Foundation FS/14/5/30533
6 · The paper itself

Abstract

The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current,

Indexed as

arrhythmiaclass 1a anti-arrhythmicsdrug modelinghuman ventriclespotassium channelsshort QT syndrome

Identifiers

PMID29085299
PMCPMC5649182
OpenAlexW2758962074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.