Evidence map›Paper›PMID 29085257›Full record

Trial reportTransactions of the American Ophthalmological Society2017

Evaluation of Visual Field and Imaging Outcomes for Glaucoma Clinical Trials (An American Ophthalomological Society Thesis).

David F Garway-Heath, Ana Quartilho, Philip Prah, David P Crabb, Qian Cheng, Haogang Zhu

Abstract readRandomized Controlled Trial
PubMed Full text at PMC
In one paragraph

Trial report in Transactions of the American Ophthalmological Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Visual field progression in Asian glaucoma patients: a 10-year stratified cohort analysis from a national health system with universal coverage.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Hierarchical Censored Bayesian Analysis of Visual Field Progression.Translational vision science & technology · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David F Garway-HeathNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (Garway-Heath, Quartilho, Prah), Division of Optometry and Visual Science, School of Health Sciences, City, University of London, UK (Crabb), School of Computer Science and Engineering, Beihang University, Beijing, China (Cheng, Zhu).
Ana QuartilhoNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (Garway-Heath, Quartilho, Prah), Division of Optometry and Visual Science, School of Health Sciences, City, University of London, UK (Crabb), School of Computer Science and Engineering, Beihang University, Beijing, China (Cheng, Zhu).
Philip PrahNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (Garway-Heath, Quartilho, Prah), Division of Optometry and Visual Science, School of Health Sciences, City, University of London, UK (Crabb), School of Computer Science and Engineering, Beihang University, Beijing, China (Cheng, Zhu).
David P CrabbNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (Garway-Heath, Quartilho, Prah), Division of Optometry and Visual Science, School of Health Sciences, City, University of London, UK (Crabb), School of Computer Science and Engineering, Beihang University, Beijing, China (Cheng, Zhu).
Qian ChengNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (Garway-Heath, Quartilho, Prah), Division of Optometry and Visual Science, School of Health Sciences, City, University of London, UK (Crabb), School of Computer Science and Engineering, Beihang University, Beijing, China (Cheng, Zhu).
Haogang ZhuNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK (Garway-Heath, Quartilho, Prah), Division of Optometry and Visual Science, School of Health Sciences, City, University of London, UK (Crabb), School of Computer Science and Engineering, Beihang University, Beijing, China (Cheng, Zhu).

Funding

Department of Health 11/129/245
6 · The paper itself

Abstract

purposeTo evaluate the ability of various visual field (VF) analysis methods to discriminate treatment groups in glaucoma clinical trials and establish the value of time-domain optical coherence tomography (TD OCT) imaging as an additional outcome.

methodsVFs and retinal nerve fibre layer thickness (RNFLT) measurements (acquired by TD OCT) from 373 glaucoma patients in the UK Glaucoma Treatment Study (UKGTS) at up to 11 scheduled visits over a 2 year interval formed the cohort to assess the sensitivity of progression analysis methods. Specificity was assessed in 78 glaucoma patients with up to 11 repeated VF and OCT RNFLT measurements over a 3 month interval. Growth curve models assessed the difference in VF and RNFLT rate of change between treatment groups. Incident progression was identified by 3 VF-based methods: Guided Progression Analysis (GPA), 'ANSWERS' and 'PoPLR', and one based on VFs and RNFLT: 'sANSWERS'. Sensitivity, specificity and discrimination between treatment groups were evaluated.

resultsThe rate of VF change was significantly faster in the placebo, compared to active treatment, group (-0.29 vs +0.03 dB/year,

conclusionsAlthough the VF progression-detection method including VF and RNFLT measurements is more sensitive, it does not improve discrimination between treatment arms.

Indexed as

Intraocular PressureAgedAged, 80 and overDisease ProgressionFemaleFollow-Up StudiesGlaucomaHumansMaleMiddle AgedOphthalmologyRetinal Ganglion CellsSocieties, MedicalTomography, Optical CoherenceUnited StatesVisual Fields

Identifiers

PMID29085257
PMCPMC5652981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.