Evidence map›Paper›PMID 29085228›Full record

ArticleWorld journal of gastroenterology2017

Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features.

Diego Marques, Layse Raynara Ferreira-Costa, Lorenna Larissa Ferreira-Costa, Romualdo da Silva Correa, Aline Maciel Pinheiro Borges, Fernanda Ribeiro Ito, Carlos Cesar de Oliveira Ramos, Raul Hernandes Bortolin, André Ducati Luchessi, Ândrea Ribeiro-Dos-Santos and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Renin-angiotensin system gene polymorphisms and colorectal cancer risk: a meta-analysis.Journal of the renin-angiotensin-aldosterone system : JRAAS
    Pooled it
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  9. Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
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  11. Association ofPharmaceutics · 2022
    Article
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  15. piRNAs in Gastric Cancer: A New Approach Towards Translational Research.International journal of molecular sciences · 2020
    Review
  16. Detection of rs665862918 (15-bp Indel) of theAnimals : an open access journal from MDPI · 2020
    Article
  17. Article
  18. Journal of Cancer · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Diego MarquesLaboratório de Bioanálise e Biotecnologia Molecular, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Rio Grande do Norte, Brazil.
Layse Raynara Ferreira-CostaLaboratório de Bioanálise e Biotecnologia Molecular, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Rio Grande do Norte, Brazil.
Lorenna Larissa Ferreira-CostaLaboratório de Bioanálise e Biotecnologia Molecular, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Rio Grande do Norte, Brazil.
Romualdo da Silva CorreaDepartamento de Cirurgia Oncológica, Liga Norte Riograndense Contra o Câncer, Natal 59040-000, Rio Grande do Norte, Brazil.
Aline Maciel Pinheiro BorgesDepartamento de Cirurgia Oncológica, Liga Norte Riograndense Contra o Câncer, Natal 59040-000, Rio Grande do Norte, Brazil.
Fernanda Ribeiro ItoDepartamento de Cirurgia Oncológica, Liga Norte Riograndense Contra o Câncer, Natal 59040-000, Rio Grande do Norte, Brazil.
Carlos Cesar de Oliveira RamosLaboratório de Patologia e Citopatologia, Liga Norte Riograndense Contra o Câncer, Natal 59040-000, Rio Grande do Norte, Brazil.
Raul Hernandes BortolinLaboratório de Bioanálise e Biotecnologia Molecular, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Rio Grande do Norte, Brazil.
André Ducati LuchessiLaboratório de Bioanálise e Biotecnologia Molecular, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Rio Grande do Norte, Brazil.
Ândrea Ribeiro-Dos-SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66055-080, Pará, Brazil.
Sidney SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66055-080, Pará, Brazil.
Vivian Nogueira SilbigerLaboratório de Bioanálise e Biotecnologia Molecular, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Rio Grande do Norte, Brazil.
Universidade Federal do Pará · BRUniversidade Federal do Rio Grande do Norte · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the association between 16 insertion-deletions (INDEL) polymorphisms, colorectal cancer (CRC) risk and clinical features in an admixed population.

methodsOne hundred and forty patients with CRC and 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on GeneMapper ID v3.2. Clinicopathological data were obtained by consulting the patients' clinical charts, intra-operative documentation, and pathology scoring.

resultsLogistic regression analysis showed that polymorphism variations in

conclusionThe INDEL variations in

Indexed as

Genetic Predisposition to DiseaseAdultAgedAged, 80 and overBrazilCase-Control StudiesColorectal NeoplasmsElectrophoresis, CapillaryFemaleGenotypeGenotyping TechniquesHumansIncidenceINDEL MutationMaleMiddle AgedAdmixed populationClinical featuresColorectal cancerDiagnosticIns-del polymorphismPotential biomarkerPrognosticRisk stratification

Identifiers

PMID29085228
PMCPMC5645618
OpenAlexW2759224072

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.