Evidence map›Paper›PMID 29085225›Full record

ArticleWorld journal of gastroenterology2017

Glycosylation-related gene expression in HT29-MTX-E12 cells upon infection by

Michael T Cairns, Ananya Gupta, Julie A Naughton, Marian Kane, Marguerite Clyne, Lokesh Joshi

Abstract read
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Bacteriophages evolve enhanced persistence to a mucosal surface.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
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  11. Frontiers in nutrition · 2021
    Article
  12. Foods (Basel, Switzerland) · 2020
    Article
  13. Intestinal mucus is capable of stabilizing supersaturation of poorly water-soluble drugs.Journal of controlled release : official journal of the Controlled Release Society · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michael T CairnsGlycoscience Group, National Centre for Biomedical Engineering Science, National University of Ireland Galway, H91 CF50 Galway, Ireland. michael.cairns@nuigalway.ie.
Ananya GuptaSchool of Natural Sciences, National University of Ireland Galway, H91 CF50 Galway, Ireland.
Julie A NaughtonConway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland.
Marian KaneGlycoscience Group, National Centre for Biomedical Engineering Science, National University of Ireland Galway, H91 CF50 Galway, Ireland.
Marguerite ClyneConway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland.
Lokesh JoshiGlycoscience Group, National Centre for Biomedical Engineering Science, National University of Ireland Galway, H91 CF50 Galway, Ireland.
Ollscoil na Gaillimhe – University of Galway · IEUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo identify glycosylation-related genes in the HT29 derivative cell line, HT29-MTX-E12, showing differential expression on infection with

methodsPolarised HT29-MTX-E12 cells were infected for 24 h with

resultsInfection of host cells was confirmed by the isolation of live bacteria after 24 h incubation and by PCR amplification of bacteria-specific genes from the host cell RNA.

conclusionGene expression data suggest that infection with

Indexed as

Host-Pathogen InteractionsDown-RegulationGene Expression ProfilingGene OntologyGlycosylationHelicobacter InfectionsHelicobacter pyloriHT29 CellsHumansMicroarray AnalysisMucinsPancreatitis-Associated ProteinsPolysaccharidesMUC20 protein, humanMucinsPancreatitis-Associated ProteinsPolysaccharidesREG4 protein, humanAdherent mucusGastricGlycosylationH. pylori strain 26695HT29-MTX-E12Transcriptomics

Identifiers

PMID29085225
PMCPMC5645615
OpenAlexW2757865255

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.