Evidence map›Paper›PMID 29085215›Full record

ArticleWorld journal of gastroenterology2017

Serum angiotensin-converting enzyme level for evaluating significant fibrosis in chronic hepatitis B.

Ryuichi Noguchi, Kosuke Kaji, Tadashi Namisaki, Kei Moriya, Mitsuteru Kitade, Kosuke Takeda, Hideto Kawaratani, Yasushi Okura, Yosuke Aihara, Masanori Furukawa and 2 more

Open access · hybridAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. [Hepatic granuloma-A diagnostic challenge].Zeitschrift fur Rheumatologie · 2022
    Review
  7. Article
  8. Review
  9. Performance of common imaging techniquesWorld journal of clinical cases · 2019
    Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ryuichi NoguchiThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Kosuke KajiThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan. kajik@naramed-u.ac.jp.
Tadashi NamisakiThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Kei MoriyaThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Mitsuteru KitadeThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Kosuke TakedaThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Hideto KawarataniThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Yasushi OkuraThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Yosuke AiharaThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Masanori FurukawaThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Akira MitoroThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Hitoshi YoshijiThird Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Nara Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the diagnostic performance of angiotensin-converting enzyme (ACE) on significant liver fibrosis in patients with chronic hepatitis B (CHB).

methodsIn total, 100 patients with CHB who underwent liver biopsy in our hospital were enrolled, and 70 patients except for 30 patients with hypertension, fatty liver or habitual alcoholic consumption were analyzed. We compared histological liver fibrosis and serum ACE levels and evaluated the predictive potential to diagnose significant liver fibrosis by comparison with several biochemical marker-based indexes such as the aspartate aminotransferase (AST)-to-platelet ratio index (APRI), the fibrosis index based on four factors (FIB-4), the Mac-2 binding protein glycosylation isomer (M2BPGi) level and the number of platelets (Plt).

resultsSerum ACE levels showed moderately positive correlation with liver fibrotic stages (

conclusionThe serum ACE level could be a novel noninvasive, easy, accurate, and inexpensive marker of significant fibrosis stage in patients with CHB.

Indexed as

AdultAntigens, NeoplasmAspartate AminotransferasesBiomarkersBiopsyFemaleHepatitis B, ChronicHumansLiverLiver CirrhosisMaleMembrane GlycoproteinsMiddle AgedPeptidyl-Dipeptidase APlatelet CountROC CurveACE protein, humanAntigens, NeoplasmAspartate AminotransferasesBiomarkersMembrane GlycoproteinsPeptidyl-Dipeptidase ATAA90K protein, humanAngiotensin-converting enzymeAspartate aminotransferase-to-platelet ratio indexFibrosis index based on four factorsHepatitis B virusLiver fibrosisMac-2 binding protein glycosylation isomerNoninvasive fibrosis marker

Identifiers

PMID29085215
PMCPMC5643291
OpenAlexW2758543052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.