ArticleScientific reports2017
Theta and Alpha Oscillation Impairments in Autistic Spectrum Disorder Reflect Working Memory Deficit.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05291208 (Evaluation of a Cognitive Training Therapy Based on Synchronized Oscillatory Stimulation in Patients With Mild Cognitive Impairment Through a Randomized Clinical Trial), which is not on this map. Cited by 38 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of a Cognitive Training Therapy Based on Synchronized Oscillatory Stimulation in Patients With Mild Cognitive Impairment Through a Randomized Clinical Trial
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Non-Invasive BCI-VR Applied Protocols as Intervention Paradigms on School-Aged Subjects with ASD: A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- Oscillatory activity underlying cognitive performance in children and adolescents with autism: a systematic review.Frontiers in human neuroscience · 2024Pooled it
- Brain correlates of declarative memory atypicalities in autism: a systematic review of functional neuroimaging findings.Molecular autism · 2023Pooled it
- Deep white-matter tracts link docosahexaenoic acid status to cognitive performance in human adolescents.iScience · 2026Article
- Global neural oscillations underlie performance variability and attentional state fluctuations in humans.Scientific reports · 2026Article
- Functional connectivity in infants' visual cortex and its links to motion processing and autism.Scientific reports · 2026Article
- Theta-gamma phase amplitude coupling serves as a marker of social cognition and visual working memory deficits in individuals with elevated autistic traits.Communications psychology · 2026Article
- Neuroimmune Clearance and EEG Biomarkers: A Unified Model of ASD and Dyslexia.Neural plasticity · 2026Review
- Coupling between neural oscillations and white matter integrity reveals cognitive computational profiles following COVID-19.Scientific reports · 2025Article
- Autism spectrum disorder disrupts brain network connectivity maturation during childhood development.Scientific reports · 2025Article
- Targeted Endogenous Bioelectric Modulation in Autism Spectrum Disorder: Real-World Clinical Outcomes of the REAC BWO Neurodevelopment-Autism Protocol.Journal of clinical medicine · 2025Article
- Attention-Dependent but not Pre-attentive Neural Markers of Auditory Change Process are Atypical in Adults With Autism Spectrum Conditions.Journal of autism and developmental disorders · 2025Article
- A role for preparatory midfrontal theta in autism as revealed by a high executive load brain-computer interface reverse spelling task.Scientific reports · 2025Article
- Electroencephalography in Autism Spectrum Disorder.Journal of clinical medicine · 2025Review
- Neural mechanisms of spatial navigation in ASD and TD children: insights from EEG microstate and functional connectivity analysis.Frontiers in psychiatry · 2025Article
- zBMI scales with multispectral alterations in the neural oscillatory dynamics serving verbal working memory in youth.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Lateral prefrontal theta oscillations causally drive a computational mechanism underlying conflict expectation and adaptation.Nature communications · 2024Article
- Interplay between preclinical indices of obesity and neural signatures of fluid intelligence in youth.Communications biology · 2024Article
- Abnormalities in both stimulus-induced and baseline MEG alpha oscillations in the auditory cortex of children with Autism Spectrum Disorder.Brain structure & function · 2024Article
- Theta and alpha oscillations may underlie improved attention and working memory in musically trained children.Brain and behavior · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A dysfunction in the excitatory-inhibitory (E/I) coordination in neuronal assembly has been proposed as a possible neurobiological mechanism of Autistic Spectrum Disorder (ASD). However, the potential impact of this mechanism in cognitive performance is not fully explored. Since the main consequence of E/I dysfunction is an impairment in oscillatory activity and its underlying cognitive computations, we assessed the electroencephalographic activity of ASD and typically developing (TD) subjects during a working-memory task. We found that ASD subjects committed more errors than TD subjects. Moreover, TD subjects demonstrated a parametric modulation in the power of alpha and theta band while ASD subjects did not demonstrate significant modulations. The preceding leads to significant differences between the groups in both the alpha power placed on the occipital cortex and the theta power placed on the left premotor and the right prefrontal cortex. The impaired theta modulation correlated with autistic symptoms. The results indicated that ASD may present an alteration in the recruitment of the oscillatory activity during working-memory, and this alteration could be related to the physiopathology of the disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.