ArticleScientific reports2017
A platform for stereological quantitative analysis of the brain-wide distribution of type-specific neurons.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Uniform volumetric single-cell processing for organ-scale molecular phenotyping.Nature biotechnology · 2025Article
- Molecularly defined cellular atlas of the entire mouse brain with isotropic single-cell resolution.Nature communications · 2025Article
- Brain-wide mapping of c-Fos expression in nitroglycerin-induced models of migraine.The journal of headache and pain · 2024Article
- Whole-brain Optical Imaging: A Powerful Tool for Precise Brain Mapping at the Mesoscopic Level.Neuroscience bulletin · 2023Review
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- Accurate classification of major brain cell types using in vivo imaging and neural network processing.PLoS biology · 2023Article
- Somatostatin signaling modulates binge drinking behavior via the central nucleus of the amygdala.Neuropharmacology · 2023Article
- A rapid workflow for neuron counting in combined light sheet microscopy and magnetic resonance histology.Frontiers in neuroscience · 2023Article
- Alteration in the number of neuronal and non-neuronal cells in mouse models of obesity.Brain communications · 2023Article
- A method to estimate the cellular composition of the mouse brain from heterogeneous datasets.PLoS computational biology · 2022Article
- Brain-wide mapping of c-Fos expression with fluorescence micro-optical sectioning tomography in a chronic sleep deprivation mouse model.Neurobiology of stress · 2022Article
- Constructing the rodent stereotaxic brain atlas: a survey.Science China. Life sciences · 2022Review
- CUBIC-Cloud provides an integrative computational framework toward community-driven whole-mouse-brain mapping.Cell reports methods · 2021Article
- Densities and numbers of calbindin and parvalbumin positive neurons across the rat and mouse brain.iScience · 2021Article
- Whole-Brain Reconstruction of Neurons in the Ventral Pallidum Reveals Diverse Projection Patterns.Frontiers in neuroanatomy · 2021Article
- Recent Trends and Perspectives in Cerebral Organoids Imaging and Analysis.Frontiers in neuroscience · 2021Review
- A Robust Image Registration Interface for Large Volume Brain Atlas.Scientific reports · 2020Article
- Review of micro-optical sectioning tomography (MOST): technology and applications for whole-brain optical imaging [Invited].Biomedical optics express · 2019Article
- Challenges of Processing and Analyzing Big Data in Mesoscopic Whole-brain Imaging.Genomics, proteomics & bioinformatics · 2019Article
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7 authors.
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Abstract
Quantifying the distribution of specific neurons throughout the whole brain is crucial for understanding physiological actions, pathological alterations and pharmacological treatments. However, the precise cell number and density of specific neurons in the entire brain remain unknown because of a lack of suitable research tools. Here, we propose a pipeline to automatically acquire and analyse the brain-wide distribution of type-specific neurons in a mouse brain. We employed a Brain-wide Positioning System to collect high-throughput anatomical information with the co-localized cytoarchitecture of the whole brain at subcellular resolution and utilized the NeuroGPS algorithm to locate and count cells in the whole brain. We evaluated the data continuity of the 3D dataset and the accuracy of stereological cell counting in 3D. To apply this pipeline, we acquired and quantified the brain-wide distributions and somatic morphology of somatostatin-expressing neurons in transgenic mouse brains. The results indicated that this whole-brain cell counting pipeline has the potential to become a routine tool for cell type neuroscience studies.
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