ArticleScientific reports2017
Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- 4-Galactosylkojibiose Extends the Lifespan ofNutrients · 2026Article
- The impact of sugar diet on humidity preference, survival, and host landing in mosquitoes.Journal of medical entomology · 2025Article
- Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila.Scientific reports · 2025Article
- Preference of position in the proximity of various sugars revealed by location analysis of Drosophila melanogaster.Scientific reports · 2024Article
- A phosphorylation-deficient mutant ofFrontiers in neuroscience · 2023Article
- The interplay between macronutrients and sleep: focus on circadian and homeostatic processes.Frontiers in nutrition · 2023Review
- Consolidation of Sleep-Dependent Appetitive Memory Is Mediated by a Sweet-Sensing Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Manipulations of the olfactory circuit highlight the role of sensory stimulation in regulating sleep amount.Sleep · 2021Article
- Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity.PLoS genetics · 2020Article
- A single pair of leucokinin neurons are modulated by feeding state and regulate sleep-metabolism interactions.PLoS biology · 2019Article
- Sleep inFrontiers in physiology · 2019Review
- Serine metabolism in the brain regulates starvation-induced sleep suppression inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Dietary Zinc Acts as a Sleep Modulator.International journal of molecular sciences · 2017Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Starvation reduces sleep in various animal species including humans and fruit flies. Immediate hunger and the following insufficient nutritional status resulting from starvation may affect sleep and arousal differently. In order to clarify the mechanism underlying the relationship between diet and sleep, we analysed the sleep behaviour of Drosophila melanogaster that were either starved or fed with different types of sugars. Starved flies showed longer activity bouts, short sleep bouts and a decreased arousal threshold. Non-nutritive sweeteners such as sucralose and arabinose, which are sweet but not nutritive, induced sleep in starved flies, but sleep bout length and the arousal threshold was short and decreased, respectively. On the other hand, sorbitol, which is not sweet but nutritive, did not induce sleep, but slightly increased the lowered arousal threshold. Activation of sweetness receptor expressing neurons induced sleep in starved flies. These results suggest that sweetness alone is sufficient to induce sleep in starved flies and that the nutritional status affects sleep homeostasis by decreasing the arousal threshold, which resulted in short sleep bouts in Drosophila.
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