ArticleScientific reports2017
Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax - a liver transcriptomics approach.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Mitogenome Characterization and Phylogenetic Insights Into Blind Mole Rats,Ecology and evolution · 2026Article
- Adaptation of the Spalax galili transcriptome to hypoxia may underlie the complex phenotype featuring longevity and cancer resistance.npj aging · 2025Article
- Hypoxic and hypercapnic burrow conditions lead to downregulation of free triiodothyronine and hematocrit in Ansell's mole-rats (Fukomys anselli).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Hypoxia modeling techniques: A review.Heliyon · 2023Review
- Review
- Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models.Frontiers in aging · 2022Review
- Gut Microbiome Alterations and Hepatic Metabolic Flexibility in the Gansu Zokor,Frontiers in cardiovascular medicine · 2022Article
- The hypoxia adaptation of small mammals to plateau and underground burrow conditions.Animal models and experimental medicine · 2021Review
- Identification and Functional Analysis of lncRNAs Responsive to Hypoxia inCurrent issues in molecular biology · 2021Article
- Local adaptations of Mediterranean sheep and goats through an integrative approach.Scientific reports · 2021Article
- Glutamine Homeostasis and Its Role in the Adaptive Strategies of the Blind Mole Rat, Spalax.Metabolites · 2021Article
- Comprehensive Analysis ofMetabolites · 2021Article
- Nontraditional systems in aging research: an update.Cellular and molecular life sciences : CMLS · 2021Review
- Distinct organization of adaptive immunity in the long-lived rodent Spalax galili.Nature aging · 2021Article
- Transcriptome analysis of the liver ofPeerJ · 2021Article
- The mTORC1/eIF4E/HIF-1α Pathway Mediates Glycolysis to Support Brain Hypoxia Resistance in the Gansu Zokor,Frontiers in physiology · 2021Article
- The occurrence of cancer in vertebrates: a mini review.Journal of biological research (Thessalonike, Greece) · 2020Review
- Genome-Protecting Compounds as Potential Geroprotectors.International journal of molecular sciences · 2020Review
- Comparative morphometric analysis of lungs of the semifossorial giant pouched rat (Cricetomys gambianus) and the subterranean Nigerian mole rat (Cryptomys foxi).Scientific reports · 2020Article
- Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The blind subterranean mole rat Spalax shows a remarkable tolerance to hypoxia, cancer-resistance and longevity. Unravelling the genomic basis of these adaptations will be important for biomedical applications. RNA-Seq gene expression data were obtained from normoxic and hypoxic Spalax and rat liver tissue. Hypoxic Spalax broadly downregulates genes from major liver function pathways. This energy-saving response is likely a crucial adaptation to low oxygen levels. In contrast, the hypoxia-sensitive rat shows massive upregulation of energy metabolism genes. Candidate genes with plausible connections to the mole rat's phenotype, such as important key genes related to hypoxia-tolerance, DNA damage repair, tumourigenesis and ageing, are substantially higher expressed in Spalax than in rat. Comparative liver transcriptomics highlights the importance of molecular adaptations at the gene regulatory level in Spalax and pinpoints a variety of starting points for subsequent functional studies.
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