ArticleScientific reports2017
The Effects of Serum Proteins on Magnesium Alloy Degradation in Vitro.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 51 citations in OpenAlex.
- Synergistic Effects of Magnesium Ions and Hydrogen Gas in Biodegradable Mg Implants: Mechanisms, Therapeutic Windows, and Translational Perspectives.Annals of biomedical engineering · 2026Review
- Experimental study on the application of a novel degradable calcium-phosphate coated magnesium alloy encircling bone plate in the internal fixation of rib fractures.Journal of materials science. Materials in medicine · 2026Article
- Mg-Y-Nd alloy biocorrosion behavior in hyperlipidemia models in vitro and in vivo.Acta biomaterialia · 2026Article
- Towards Accurate Biocompatibility: Rethinking Cytotoxicity Evaluation for Biodegradable Magnesium Alloys in Biomedical Applications.Journal of functional biomaterials · 2024Article
- Review
- Recent research advances on corrosion mechanism and protection, and novel coating materials of magnesium alloys: a review.RSC advances · 2023Review
- Morphological and Surface Potential Characterization of Protein Nanobiofilm Formation on Magnesium Alloy Oxide: Their Role in Biodegradation.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Clinical translation and challenges of biodegradable magnesium-based interference screws in ACL reconstruction.Bioactive materials · 2021Review
- Albumins inhibit the corrosion of absorbable Zn alloys at initial stages of degradation.Surface innovations · 2020Article
- In vitro degradation of pure magnesium-the synergetic influences of glucose and albumin.Bioactive materials · 2020Article
- A portable device for studying the effects of fluid flow on degradation properties of biomaterials inside cell incubators.Regenerative biomaterials · 2019Article
- Degradation of Bioresorbable Mg-4Zn-1Sr Intramedullary Pins and Associated Biological Responses in Vitro and in Vivo.ACS applied materials & interfaces · 2017Article
- Nanomaterials for treating cardiovascular diseases: A review.Bioactive materials · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnesium (Mg) alloys are promising materials for biodegradable implants, but their clinical translation requires improved control over their degradation rates. Proteins may be a major contributing factor to Mg alloy degradation, but are not yet fully understood. This article reports the effects of fetal bovine serum (FBS), a physiologically relevant mixture of proteins, on Mg and Mg alloy degradation. FBS had little impact on mass loss of pure Mg during immersion degradation, regardless of whether or not a native oxide layer was present on the sample surface. FBS reduced the mass loss of Mg-Yttrium (MgY) alloy with an oxidized surface during immersion degradation, but increased the mass loss for the same alloy with a metallic surface (surface oxides were removed). FBS also influenced the mode of degradation by limiting the depth of pit formation during degradation processes on commercially pure Mg with metallic or oxidized surfaces and on MgY alloy with oxidized surfaces. The results demonstrated that serum proteins had significant interactions with Mg-based biodegradable metals, and these interactions may be modified by alloy composition and processing. Therefore, proteins should be taken into account when designing experiments to assess degradation of Mg-based implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.