ArticleNature communications2017
Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- A flexible repertoire of wound closure strategies precedes whole-body regeneration.Nature communications · 2026Article
- Dynamic cell fate transitions during morphallactic regeneration.Nature communications · 2026Article
- Injury-induced Neuregulin-EGFR signaling from muscle mobilizes stem cells for whole-body regeneration in acoels.Developmental biology · 2025Article
- Chromatin profiling data indicate regulatory mechanisms for differentiation during development in the acoel Hofstenia miamia.Development (Cambridge, England) · 2025Article
- Acoel single-cell atlas reveals expression dynamics and heterogeneity of adult pluripotent stem cells.Nature communications · 2023Article
- The salamander blastema within the broader context of metazoan regeneration.Frontiers in cell and developmental biology · 2023Review
- A Wnt11 and Dishevelled signaling pathway acts prior to injury to control wound polarization for the onset of planarian regeneration.Current biology : CB · 2022Article
- Positional Information and Stem Cells Combine to Result in Planarian Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
- The Hazards of Regeneration: From Morgan's Legacy to Evo-Devo.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Transcription Factors Active in the Anterior Blastema ofBiomolecules · 2021Article
- Transgenesis in the acoel worm Hofstenia miamia.Developmental cell · 2021Article
- Comparative Aspects of Annelid Regeneration: Towards Understanding the Mechanisms of Regeneration.Genes · 2021Review
- Acoel Single-Cell Transcriptomics: Cell Type Analysis of a Deep Branching Bilaterian.Molecular biology and evolution · 2021Article
- Animal regeneration in the era of transcriptomics.Cellular and molecular life sciences : CMLS · 2021Review
- WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Proliferation during Planarian Regeneration.Genes · 2021Article
- Pattern regulation in a regenerating jellyfish.eLife · 2020Article
- Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment.PLoS genetics · 2020Article
- Does regeneration recapitulate phylogeny? Planaria as a model of body-axis specification in ancestral eumetazoa.Communicative & integrative biology · 2020Article
- A small set of conserved genes, including sp5 and Hox, are activated by Wnt signaling in the posterior of planarians and acoels.PLoS genetics · 2019Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Positional information is required for animal regeneration, yet how it is harbored in adult tissues is poorly understood. In planarians, positional control genes (PCGs) control regeneration outcomes and are regionally expressed predominately in the musculature. Acoels are early diverging bilaterally symmetric animals, having separated from other bilaterians > 550 million years ago. Here, we find that PCGs in the acoel Hofstenia miamia are expressed together and specifically in a primary differentiated cell type: muscle. The vast majority of Hofstenia muscle cells in regions tested express PCGs, suggesting positional information is a major feature of muscle. PCG expression domains are dynamic in muscle after injury, consistent with known PCG roles in guiding regeneration. These data demonstrate an instructive positional role for Hofstenia muscle and this similarity with planarians suggests mesodermal muscle originated at the base of the Bilateria not only for contraction, but also as the source of positional information guiding regeneration.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.