Evidence map›Paper›PMID 29084899›Full record

ArticleInfection and immunity2018

Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2.

John Ruby, Michael Martin, Michael J Passineau, Valentina Godovikova, J Christopher Fenno, Hui Wu

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Immunological response of live-captured wild elk (Frontiers in veterinary science · 2025
    Article
  7. Article
  8. Review
  9. Oral SpirocheteInternational journal of molecular sciences · 2023
    Article
  10. Review
  11. The pathogenic mechanism of oral bacteria and treatment with inhibitors.Clinical and experimental dental research · 2022
    Review
  12. Article
  13. Article
  14. Frontiers in cellular and infection microbiology · 2021
    Article
  15. Approaches to Understanding Mechanisms of Dentilisin Protease Complex Expression inFrontiers in cellular and infection microbiology · 2021
    Review
  16. Article
  17. Infection and atherosclerosis: TLR-dependent pathways.Cellular and molecular life sciences : CMLS · 2020
    Review
  18. Escape of TLR5 Recognition byFrontiers in immunology · 2020
    Article
  19. Oral Mucosal Epithelial Cells.Frontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

John RubyDepartment of Pediatric Dentistry, School of Dentistry, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Michael MartinDepartment of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Michael J PassineauGene Therapy Program, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.
Valentina GodovikovaDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.
J Christopher FennoDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.
Hui WuDepartment of Pediatric Dentistry, School of Dentistry, The University of Alabama at Birmingham, Birmingham, Alabama, USA hwu@uab.edu.
University of Alabama at Birmingham · USUniversity of Michigan–Ann Arbor · USAllegheny Health Network · USUniversity of Louisville · US

Funding

Mucosal HIV and Immunobiology CenterR24DK064400 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SMITH, PHILLIP D · 2003 to 2012
$4.8M
Biosynthesis and Function of Treponema denticola LipooligosaccharideR21DE022575 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WU, HUI · 2012 to 2013
$396k
Treponema Denticola-Innate Immune System InteractionsR03DE016040 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RUBY, JOHN DAWSON · 2005 to 2006
$144k
NIDCR NIH HHS R03 DE016040NIDCR NIH HHS R21 DE022575NIDDK NIH HHS R24 DK064400
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cells, CulturedFlagellaGingivaHEK293 CellsHumansImmunity, InnateInflammationInterleukin-10Interleukin-1betaInterleukin-6Leukocytes, MononuclearMonocytesNF-kappa BPathogen-Associated Molecular Pattern MoleculesToll-Like Receptor 2Treponema denticolaInterleukin-10Interleukin-1betaInterleukin-6NF-kappa BPathogen-Associated Molecular Pattern MoleculesTLR2 protein, humanToll-Like Receptor 2Tumor Necrosis Factor-alphaflagellainnate immunityToll-like receptorsTreponema denticola

Identifiers

PMID29084899
PMCPMC5736820
OpenAlexW2765851697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.