Evidence map›Paper›PMID 29084896›Full record

ArticleInfection and immunity2018

Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide.

Katrin Anne Becker, Björn Fahsel, Hannes Kemper, Joelina Mayeres, Cao Li, Barbara Wilker, Simone Keitsch, Matthias Soddemann, Carolin Sehl, Marcus Kohnen and 6 more

Abstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025
    Review
  8. Article
  9. From defense to disease: the multifaceted role of lymphatics during infection.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  10. The virulence toolkit of Staphylococcus aureus: a comprehensive review of toxin diversity, molecular mechanisms, and clinical implications.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  11. The endothelium at the interface between tissues andClinical microbiology reviews · 2025
    Review
  12. Strategies for Survival ofInternational journal of molecular sciences · 2025
    Review
  13. DecipheringmSystems · 2024
    Article
  14. Review
  15. ADAM10-a "multitasker" in sepsis: focus on its posttranslational target.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  16. Review
  17. Ceramide in cerebrovascular diseases.Frontiers in cellular neuroscience · 2023
    Review
  18. Article
  19. Exploring the Role ofToxins · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Katrin Anne BeckerDepartment of Molecular Biology, Medical School, University of Duisburg-Essen, Essen, Germany katrin.anne.becker@uni-due.de erich.gulbins@uni-due.de.
Björn Fahsel *Gymnasium Essen-Werden, Essen, Germany.
Hannes Kemper *Gymnasium Essen-Werden, Essen, Germany.
Joelina Mayeres *Gymnasium Essen-Werden, Essen, Germany.
Cao LiDepartment of Molecular Biology, Medical School, University of Duisburg-Essen, Essen, Germany.
Barbara WilkerDepartment of Molecular Biology, Medical School, University of Duisburg-Essen, Essen, Germany.
Simone KeitschDepartment of Molecular Biology, Medical School, University of Duisburg-Essen, Essen, Germany.
Matthias SoddemannDepartment of Molecular Biology, Medical School, University of Duisburg-Essen, Essen, Germany.
Carolin SehlDepartment of Molecular Biology, Medical School, University of Duisburg-Essen, Essen, Germany.
Marcus KohnenGymnasium Essen-Werden, Essen, Germany.
Michael J EdwardsDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Heike GrassméGymnasium Essen-Werden, Essen, Germany.
Charles C CaldwellDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID http://orcid.org/0000-0003-1692-4550
Aaron SeitzDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Martin FraunholzChair of Microbiology, University of Würzburg, Würzburg, Germany.
Erich GulbinsDepartment of Molecular Biology, Medical School, University of Duisburg-Essen, Essen, Germany katrin.anne.becker@uni-due.de erich.gulbins@uni-due.de.
University of Duisburg-Essen · DEUniversity of Cincinnati Medical Center · USUniversity of Würzburg · DE

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Short Term Medical Student Training GrantT35DK060444 · NIDDK · UNIVERSITY OF CINCINNATI · PI JASON T BLACKARD · 2002 to 2026
$2.3M
NCATS NIH HHS UL1 TR001425NIAID NIH HHS HHSN272200700055CNIDDK NIH HHS T35 DK060444
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ADAM10 ProteinAnimalsBacterial ToxinsCells, CulturedCeramidesEndothelial CellsHemolysin ProteinsLungMiceMice, Inbred C57BLPulmonary EdemaSphingomyelin PhosphodiesteraseStaphylococcal InfectionsStaphylococcus aureusTight JunctionsADAM10 ProteinBacterial ToxinsCeramidesHemolysin ProteinsSphingomyelin Phosphodiesterasestaphylococcal alpha-toxinceramideendothelial cellssphingomyelinaseStaphylococcus aureustight junctionstoxins

Identifiers

PMID29084896
PMCPMC5736828
OpenAlexW2766832484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.