Evidence map›Paper›PMID 29084879›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

Probenecid Inhibits α-Adrenergic Receptor-Mediated Vasoconstriction in the Human Leg Vasculature.

Michael Nyberg, Peter Piil, Oliver T Kiehn, Christian Maagaard, Tue S Jørgensen, Jon Egelund, Brant E Isakson, Morten S Nielsen, Lasse Gliemann, Ylva Hellsten

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Pannexins in the vasculature.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  3. Article
  4. Pharmacology of pannexin channels.Current opinion in pharmacology · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Matching of OFrontiers in physiology · 2022
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Cardiovascular Safety of Urate Lowering Therapies.Current rheumatology reports · 2019
    Review
  15. Article
  16. Article
  17. Article
  18. Connexins and Pannexins in Vascular Function and Disease.International journal of molecular sciences · 2018
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Michael NybergFrom the Department of Nutrition, Exercise and Sports (M.N., P.P., O.T.K., C.M., T.S.J., J.E., L.G., Y.H.) and Department of Biomedical Sciences, Faculty of Health and Medical Sciences (M.S.N.), University of Copenhagen, Denmark; Department of Orthopedics, Herlev and Gentofte Hospital, Hellerup, Denmark (T.S.J.); and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville (B.E.I.).
Peter PiilFrom the Department of Nutrition, Exercise and Sports (M.N., P.P., O.T.K., C.M., T.S.J., J.E., L.G., Y.H.) and Department of Biomedical Sciences, Faculty of Health and Medical Sciences (M.S.N.), University of Copenhagen, Denmark; Department of Orthopedics, Herlev and Gentofte Hospital, Hellerup, Denmark (T.S.J.); and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville (B.E.I.).
Oliver T KiehnFrom the Department of Nutrition, Exercise and Sports (M.N., P.P., O.T.K., C.M., T.S.J., J.E., L.G., Y.H.) and Department of Biomedical Sciences, Faculty of Health and Medical Sciences (M.S.N.), University of Copenhagen, Denmark; Department of Orthopedics, Herlev and Gentofte Hospital, Hellerup, Denmark (T.S.J.); and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville (B.E.I.).
Christian MaagaardFrom the Department of Nutrition, Exercise and Sports (M.N., P.P., O.T.K., C.M., T.S.J., J.E., L.G., Y.H.) and Department of Biomedical Sciences, Faculty of Health and Medical Sciences (M.S.N.), University of Copenhagen, Denmark; Department of Orthopedics, Herlev and Gentofte Hospital, Hellerup, Denmark (T.S.J.); and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville (B.E.I.).
Tue S JørgensenFrom the Department of Nutrition, Exercise and Sports (M.N., P.P., O.T.K., C.M., T.S.J., J.E., L.G., Y.H.) and Department of Biomedical Sciences, Faculty of Health and Medical Sciences (M.S.N.), University of Copenhagen, Denmark; Department of Orthopedics, Herlev and Gentofte Hospital, Hellerup, Denmark (T.S.J.); and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville (B.E.I.).
Jon EgelundFrom the Department of Nutrition, Exercise and Sports (M.N., P.P., O.T.K., C.M., T.S.J., J.E., L.G., Y.H.) and Department of Biomedical Sciences, Faculty of Health and Medical Sciences (M.S.N.), University of Copenhagen, Denmark; Department of Orthopedics, Herlev and Gentofte Hospital, Hellerup, Denmark (T.S.J.); and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville (B.E.I.).
Brant E IsaksonFrom the Department of Nutrition, Exercise and Sports (M.N., P.P., O.T.K., C.M., T.S.J., J.E., L.G., Y.H.) and Department of Biomedical Sciences, Faculty of Health and Medical Sciences (M.S.N.), University of Copenhagen, Denmark; Department of Orthopedics, Herlev and Gentofte Hospital, Hellerup, Denmark (T.S.J.); and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville (B.E.I.).
Morten S NielsenFrom the Department of Nutrition, Exercise and Sports (M.N., P.P., O.T.K., C.M., T.S.J., J.E., L.G., Y.H.) and Department of Biomedical Sciences, Faculty of Health and Medical Sciences (M.S.N.), University of Copenhagen, Denmark; Department of Orthopedics, Herlev and Gentofte Hospital, Hellerup, Denmark (T.S.J.); and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville (B.E.I.).
Lasse GliemannFrom the Department of Nutrition, Exercise and Sports (M.N., P.P., O.T.K., C.M., T.S.J., J.E., L.G., Y.H.) and Department of Biomedical Sciences, Faculty of Health and Medical Sciences (M.S.N.), University of Copenhagen, Denmark; Department of Orthopedics, Herlev and Gentofte Hospital, Hellerup, Denmark (T.S.J.); and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville (B.E.I.).
Ylva HellstenFrom the Department of Nutrition, Exercise and Sports (M.N., P.P., O.T.K., C.M., T.S.J., J.E., L.G., Y.H.) and Department of Biomedical Sciences, Faculty of Health and Medical Sciences (M.S.N.), University of Copenhagen, Denmark; Department of Orthopedics, Herlev and Gentofte Hospital, Hellerup, Denmark (T.S.J.); and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville (B.E.I.). yhellsten@nexs.ku.dk.
Gentofte Hospital · DK

Funding

Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A., RAVICHANDRAN, KODI S · 2014 to 2023
$24.0M
NHLBI NIH HHS P01 HL120840
6 · The paper itself

Abstract

Coordination of vascular smooth muscle cell tone in resistance arteries plays an essential role in the regulation of peripheral resistance and overall blood pressure. Recent observations in animals have provided evidence for a coupling between adrenoceptors and Panx1 (pannexin-1) channels in the regulation of sympathetic nervous control of peripheral vascular resistance and blood pressure; however, evidence for a functional coupling in humans is lacking. We determined Panx1 expression and effects of treatment with the pharmacological Panx1 channel inhibitor probenecid on the vasoconstrictor response to α1- and α2-adrenergic receptor stimulation in the human forearm and leg vasculature of young healthy male subjects (23±3 years). By use of immunolabeling and confocal microscopy, Panx1 channels were found to be expressed in vascular smooth muscle cells of arterioles in human leg skeletal muscle. Probenecid treatment increased (

Indexed as

ArteriesBlood PressureConnexinsMuscle, Smooth, VascularNerve Tissue ProteinsReceptors, AdrenergicSympathetic Nervous SystemVasoconstrictionAdrenergic Uptake InhibitorsAdultExtremitiesHumansMaleProbenecidRegional Blood FlowTyramineAdrenergic Uptake InhibitorsConnexinsNerve Tissue ProteinsPANX1 protein, humanProbenecidReceptors, AdrenergicTyramineVasoconstrictor Agentsforearmhypertensionnorepinephrinesympathetic nervous systemtyramine

Identifiers

PMID29084879
PMCPMC5876717
OpenAlexW2766697845

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.