Evidence map›Paper›PMID 29084809›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI.

Heather M Perry, Liping Huang, Rebecca J Wilson, Amandeep Bajwa, Hiromi Sesaki, Zhen Yan, Diane L Rosin, David F Kashatus, Mark D Okusa

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 1 synthesis or guideline pooled it, 178 citations in OpenAlex.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Heather M PerryDepartment of Medicine, Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine.ORCID 0000-0003-0687-5273
Liping HuangDepartment of Medicine, Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine.
Rebecca J WilsonDepartment of Medicine, Division of Cardiovascular Medicine and Center for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center, and.
Amandeep BajwaDepartment of Medicine, Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine.
Hiromi SesakiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Zhen YanDepartment of Medicine, Division of Cardiovascular Medicine and Center for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center, and.
Diane L RosinDepartments of Pharmacology and.
David F KashatusMicrobiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia; and.
Mark D OkusaDepartment of Medicine, Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, mdo7y@virginia.edu.
Immunité et Cancer · FRCardiovascular Research Center · BRJohns Hopkins University · USUniversity of Virginia · US

Funding

p38 MAPK a regulator of muscle contraction and functionR01AR050429 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI YAN, ZHEN · 2005 to 2022
$5.3M
Sphingolipids in Acute Kidney Injury and Disease ProgressionR01DK085259 · NIDDK · UNIVERSITY OF VIRGINIA · PI OKUSA, MARK DOUGLAS · 2010 to 2023
$5.0M
Leukocyte Trafficking in Acute Renal FailureR01DK062324 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI OKUSA, MARK DOUGLAS · 2003 to 2016
$4.4M
Kidney Disease and InflammationT32DK072922 · NIDDK · UNIVERSITY OF VIRGINIA · PI OKUSA, MARK DOUGLAS · 2006 to 2020
$2.6M
Ultrasound for Non-Invasive Prevention of Acute Kidney InjuryR01DK105133 · NIDDK · UNIVERSITY OF VIRGINIA · PI OKUSA, MARK DOUGLAS · 2015 to 2019
$2.4M
Exploring the Role of Mitochondrial Fission in Pancreatic TumorigenesisR01CA200755 · NCI · UNIVERSITY OF VIRGINIA · PI KASHATUS, DAVID FRANCIS · 2016 to 2020
$2.2M
Sphingosine 1 phosphate receptors 1 and 3 as novel targets in transplantationK01DK091444 · NIDDK · UNIVERSITY OF VIRGINIA · PI BAJWA, AMANDEEP · 2012 to 2016
$579k
JOEL MODEL JEM-1230 TRANSMISSION ELECTRON MICROSCOPE: PARKINSON'S DISEASES10RR021017 · NCRR · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI MACARA, IAN G · 2005 to 2005
$412k
MBF Bioscience and Zeiss Microscope System for Stereology and Tissue MorphologyS10RR026799 · NCRR · UNIVERSITY OF VIRGINIA · PI OKUSA, MARK DOUGLAS · 2010 to 2010
$278k
Ischemic Reperfusion injury in Transplantation: Role of Sphingosine 1-phosphate receptors and dendritic cellsR03DK107941 · NIDDK · UNIVERSITY OF VIRGINIA · PI BAJWA, AMANDEEP · 2016 to 2017
$158k
Endothelial sphingosine-1-phosphate receptor 1 regulates renal recovery after acute kidney injuryF32DK108563 · NIDDK · UNIVERSITY OF VIRGINIA · PI PERRY, HEATHER M. · 2015 to 2017
$115k
NCI NIH HHS R01 CA200755NCRR NIH HHS S10 RR021017NCRR NIH HHS S10 RR026799NIAMS NIH HHS R01 AR050429NIDDK NIH HHS F32 DK108563NIDDK NIH HHS K01 DK091444NIDDK NIH HHS R01 DK062324NIDDK NIH HHS R01 DK085259NIDDK NIH HHS R01 DK105133NIDDK NIH HHS R03 DK107941NIDDK NIH HHS T32 DK072922
6 · The paper itself

Abstract

The proximal tubule epithelium relies on mitochondrial function for energy, rendering the kidney highly susceptible to ischemic AKI. Dynamin-related protein 1 (DRP1), a mediator of mitochondrial fission, regulates mitochondrial function; however, the cell-specific and temporal role of DRP1 in AKI

Indexed as

3-Hydroxybutyric AcidAcute Kidney InjuryAnimalsApoptosisDisease ProgressionDynaminsFibrosisKidney Tubules, ProximalMaleMiceMice, KnockoutMitochondriaMitochondrial DynamicsNephritisOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha3-Hydroxybutyric AcidDnm1l protein, mouseDynaminsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseacute renal failurechronic kidney diseasefibrosisischemia-reperfusionmitochondriaproximal tubule

Identifiers

PMID29084809
PMCPMC5748924
OpenAlexW2766902151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.