Evidence map›Paper›PMID 29084747›Full record

ArticleAntimicrobial agents and chemotherapy2018

Teresa I Ng, Rakesh Tripathi, Thomas Reisch, Liangjun Lu, Timothy Middleton, Todd A Hopkins, Ron Pithawalla, Michelle Irvin, Tatyana Dekhtyar, Preethi Krishnan and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
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  5. Efficacy and Safety of Glecaprevir/Pibrentasvir in Patients Coinfected With Hepatitis C Virus and Human Immunodeficiency Virus Type 1: The EXPEDITION-2 Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
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  16. Cheminformatics-Based Study Identifies Potential Ebola VP40 Inhibitors.International journal of molecular sciences · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Teresa I NgAbbVie, Inc., North Chicago, Illinois, USA teresa.ng@abbvie.com.
Rakesh TripathiAbbVie, Inc., North Chicago, Illinois, USA.
Thomas ReischAbbVie, Inc., North Chicago, Illinois, USA.
Liangjun LuAbbVie, Inc., North Chicago, Illinois, USA.
Timothy MiddletonAbbVie, Inc., North Chicago, Illinois, USA.
Todd A HopkinsAbbVie, Inc., North Chicago, Illinois, USA.
Ron PithawallaAbbVie, Inc., North Chicago, Illinois, USA.
Michelle IrvinAbbVie, Inc., North Chicago, Illinois, USA.
Tatyana DekhtyarAbbVie, Inc., North Chicago, Illinois, USA.
Preethi KrishnanAbbVie, Inc., North Chicago, Illinois, USA.
Gretja SchnellAbbVie, Inc., North Chicago, Illinois, USA.
Jill BeyerAbbVie, Inc., North Chicago, Illinois, USA.
Keith F McDanielAbbVie, Inc., North Chicago, Illinois, USA.
Jun MaEnanta Pharmaceuticals Inc., Watertown, Massachusetts, USA.
Guoqiang WangEnanta Pharmaceuticals Inc., Watertown, Massachusetts, USA.
Li-Juan JiangEnanta Pharmaceuticals Inc., Watertown, Massachusetts, USA.
Yat Sun OrEnanta Pharmaceuticals Inc., Watertown, Massachusetts, USA.
Dale KempfAbbVie, Inc., North Chicago, Illinois, USA.
Tami Pilot-MatiasAbbVie, Inc., North Chicago, Illinois, USA.
Christine CollinsAbbVie, Inc., North Chicago, Illinois, USA.
AbbVie (United States) · USEnanta Pharmaceuticals (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glecaprevir (formerly ABT-493) is a novel hepatitis C virus (HCV) NS3/4A protease inhibitor (PI) with pangenotypic activity. It inhibited the enzymatic activity of purified NS3/4A proteases from HCV genotypes 1 to 6

Indexed as

Amino Acid SubstitutionAminoisobutyric AcidsAnti-HIV AgentsAntiviral AgentsCyclopropanesDEAD-box RNA HelicasesDrug Resistance, ViralDrug SynergismGenotypeHepacivirusHIV-1HumansLactams, MacrocyclicLeucineNucleoside-TriphosphataseProlineAminoisobutyric AcidsAnti-HIV AgentsAntiviral AgentsCyclopropanesDEAD-box RNA HelicasesglecaprevirLactams, MacrocyclicLeucineNS3 protein, hepatitis C virusNucleoside-TriphosphataseProlineProtease InhibitorsQuinoxalinesSerine EndopeptidasesSulfonamidesViral Nonstructural ProteinsViral ProteasesABT-493antiviral activityglecaprevirHCVNS3/4A protease inhibitorresistance

Identifiers

PMID29084747
PMCPMC5740381
OpenAlexW2765116944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.