ArticleAntimicrobial agents and chemotherapy2018
Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children.
2 registry-linked trialsOpen access · bronzeAbstract readMulticenter Study
In one paragraph
Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Trimethoprim-Sulfamethoxazole (Bactrim) Dose Optimization inInternational journal of environmental research and public health · 2022Pooled it
- Antimicrobial Treatment and Prophylaxis of Plague: Recommendations for Naturally Acquired Infections and Bioterrorism Response.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021Guideline
- Population pharmacokinetics and Monte Carlo-based dosing optimization of trimethoprim-sulfamethoxazole.Antimicrobial agents and chemotherapy · 2025Article
- Challenges for global antibiotic regimen planning and establishing antimicrobial resistance targets: implications for the WHO Essential Medicines List and AWaRe antibiotic book dosing.Clinical microbiology reviews · 2024Review
- Impact of lactoferrin supplementation on cotrimoxazole pharmacokinetics: A preliminary clinical investigation.ADMET & DMPK · 2024Article
- Selective and Concentrative Enteropancreatic Recirculation of Antibiotics by Pigs.Antibiotics (Basel, Switzerland) · 2023Article
- Oral Antibiotics for Bacteremia and Infective Endocarditis: Current Evidence and Future Perspectives.Microorganisms · 2023Review
- Developmental Pharmacokinetics of Antibiotics Used in Neonatal ICU: Focus on Preterm Infants.Biomedicines · 2023Review
- Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling.Clinical pharmacokinetics · 2022Article
- External Evaluation of Two Pediatric Population Pharmacokinetics Models of Oral Trimethoprim and Sulfamethoxazole.Antimicrobial agents and chemotherapy · 2021Observational
- First international quality control programme for laboratories measuring antimicrobial drugs to support dose individualization in critically ill patients.The Journal of antimicrobial chemotherapy · 2021Article
- Dose Optimization of Aditoprim-Sulfamethoxazole Combinations AgainstFrontiers in pharmacology · 2021Article
- Acute and long-term effects of antibiotics commonly used in laboratory animal medicine on the fecal microbiota.Veterinary research · 2020Article
- Oral Fluoroquinolone or Trimethoprim-sulfamethoxazole vs. ß-lactams as Step-Down Therapy for Enterobacteriaceae Bacteremia: Systematic Review and Meta-analysis.Open forum infectious diseases · 2019Article
- Physiologically Based Pharmacokinetic Modeling for Trimethoprim and Sulfamethoxazole in Children.Clinical pharmacokinetics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 11 institutions in 2 countries.
Julie AutmizguineResearch Center, CHU Sainte-Justine, and Department of Pharmacology and Physiology, Université de Montréal, Montreal, Quebec, Canada.
Chiara MelloniDuke Clinical Research Institute, Durham, North Carolina, USA.
Christoph P HornikDuke Clinical Research Institute, Durham, North Carolina, USA.
Samantha DallefeldDuke Clinical Research Institute, Durham, North Carolina, USA.
Barrie HarperDuke Clinical Research Institute, Durham, North Carolina, USA.
Ram YogevAnn and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Janice E SullivanUniversity of Louisville, Norton Children's Hospital and Kosair Charities Pediatric Clinical Research Unit, Louisville, Kentucky, USA.
Andrew M AtzMedical University of South Carolina, Charleston, South Carolina, USA.
Amira Al-UzriOregon Health and Science University, Portland, Oregon, USA.
Susan MendleyUniversity of Maryland School of Medicine, Baltimore, Maryland, USA.
Brenda PoindexterPerinatal Institute, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
Jeff MitchellEmmes Corporation, Rockville, Maryland, USA.
Andrew LewandowskiEmmes Corporation, Rockville, Maryland, USA.
Paula DelmoreWesley Medical Center, Wichita, Kansas, USA.
Michael Cohen-WolkowiezDuke Clinical Research Institute, Durham, North Carolina, USA.
Daniel GonzalezUNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA daniel.gonzalez@unc.edu.
the Pediatric Trials Network Steering Committee
Clinical Research Institute · USEmmes (United States) · USCentre Hospitalier Universitaire Sainte-Justine · CACincinnati Children's Hospital Medical Center · USKosair Children's Hospital · USLurie Children's Hospital · USMedical University of South Carolina · USOregon Health & Science University · USUniversity of Maryland, Baltimore · USUniversity of North Carolina at Chapel Hill · USWesley Medical Center · US
Funding
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4MUNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program-Evaluation SupplementT32GM086330 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KIM L.R. BROUWER, Daniel Gonzalez · 2011 to 2026
$8.5MPhysiologically-Based Pharmacokinetic Models for Optimal Drug Dosing in ChildrenR01HD076676 · NICHD · DUKE UNIVERSITY · PI COHEN-WOLKOWIEZ, MICHAEL · 2014 to 2017
$2.6MUse of Physiologically-Based PK/PD Models to Streamline Drug ApprovalsK23HD083465 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GONZALEZ, DANIEL · 2015 to 2019
$727kPharmacokinetics, Pharmacodynamics, and Safety of Methylprednisolone in Neonates on Cardiopulmonary BypassK23HD090239 · NICHD · DUKE UNIVERSITY · PI HORNIK, CHRISTOPH · 2017 to 2020
$646kNCATS NIH HHS UL1 TR002369NIAID NIH HHS HHSN272201300017CNIAID NIH HHS HHSN272201300017INIAID NIH HHS HHSN272201500006CNICHD NIH HHS HHSN275201000003CNICHD NIH HHS HHSN275201000003INICHD NIH HHS K23 HD083465NICHD NIH HHS K23 HD090239NICHD NIH HHS R01 HD076676NIGMS NIH HHS T32 GM086330
Abstract
Trimethoprim (TMP)-sulfamethoxazole (SMX) is used to treat various types of infections, including community-acquired methicillin-resistant
Indexed as
AdolescentAdultAnti-Bacterial AgentsChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleMethicillin-Resistant Staphylococcus aureusProspective StudiesStaphylococcal InfectionsTrimethoprim, Sulfamethoxazole Drug CombinationYoung AdultAnti-Bacterial AgentsTrimethoprim, Sulfamethoxazole Drug Combinationchildreninfantsmethicillin-resistant Staphylococcus aureuspharmacokineticssulfamethoxazoletrimethoprim
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT01431326ClinicalTrials.gov
NCT04278404ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.