Evidence map›Paper›PMID 29084556›Full record

ArticleParticle and fibre toxicology2017

Protein corona: implications for nanoparticle interactions with pulmonary cells.

Nagarjun V Konduru, Ramon M Molina, Archana Swami, Flavia Damiani, Georgios Pyrgiotakis, Paulo Lin, Patrizia Andreozzi, Thomas C Donaghey, Philip Demokritou, Silke Krol and 2 more

Open access · goldAbstract read
In one paragraph

Article in Particle and fibre toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
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  3. Advances in the Targeted Drug Delivery System for Renal Fibrosis.International journal of nanomedicine · 2026
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  8. Nanomedicine Innovations for Lung Cancer Diagnosis and Therapy.ACS applied materials & interfaces · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Nagarjun V KonduruDepartment of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.
Ramon M MolinaDepartment of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.
Archana SwamiDepartment of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.
Flavia DamianiDepartment of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.
Georgios PyrgiotakisDepartment of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.
Paulo LinDepartment of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.
Patrizia AndreozziCIC biomaGUNE Soft Matter Nanotechnology Group, Paseo de Miramón, 182, 20014, San Sebastian-Donostia, Guipuzcoa, Spain.
Thomas C DonagheyDepartment of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.
Philip DemokritouCenter for Nanotechnology and Nanotoxicology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.
Silke KrolFondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Via Amadeo 42, 20133, Milan, Italy.
Wolfgang KreylingInstitute of Epidemiology 2, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Oberschleißheim, Germany.
Joseph D BrainDepartment of Environmental Health, Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA. brain@hsph.harvard.edu.
CIC biomaGUNE · ESInstitute of Bioinformatics and Systems Biology · DEIstituto Tumori Bari · IT

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Gary Adamkiewicz · 1985 to 2026
$44.6M
Engineered Nanomaterial Synthesis, Characterization and Method Development Center for Nano-safety ResearchU24ES026946 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DEMOKRITOU, PHILIP · 2016 to 2020
$3.8M
Lipoprotein Corona Fingerprints: Implications for Pulmonary Clearance and Toxicity of Engineered NanoparticlesK99ES025813 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI KONDURU VENKATA, NAGARJUN · 2016 to 2017
$204k
NIEHS NIH HHS K99 ES025813NIEHS NIH HHS P30 ES000002NIEHS NIH HHS U24 ES026946
6 · The paper itself

Abstract

backgroundWe previously showed that cerium oxide (CeO

methodsCeO

resultsWe found that the amounts of nine proteins in the coronas formed on the four NPs varied significantly. The amounts of albumin, transferrin and α-1 antitrypsin were greater in the coronas of BaSO

conclusionsWe show that different NPs variably adsorb proteins from the lung lining fluid. The amount of albumin in the NP corona varies as does NP uptake by AMs. However, albumin coating does not affect the translocation of gold NPs across the air-blood barrier. A more extensive database of corona composition of a diverse NP library will develop a platform to help predict the effects and biokinetics of inhaled NPs.

Indexed as

Metal NanoparticlesProtein CoronaAdsorptionalpha 1-AntitrypsinAnimalsBarium SulfateBlood-Air BarrierCeriumGoldLungMacrophages, AlveolarMaleRats, WistarSerum Albumin, HumanSurface PropertiesTransferrinalpha 1-AntitrypsinBarium Sulfateceric oxideCeriumGoldProtein CoronaSerum Albumin, HumanTransferrinZinc OxideBiokineticsEngineered nanoparticlesLung macrophageNanotoxicityProtein corona

Identifiers

PMID29084556
PMCPMC5663074
OpenAlexW2766378583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.