Evidence map›Paper›PMID 29084500›Full record

Observational studyCritical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine2017

The impact of venovenous extracorporeal membrane oxygenation on cytokine levels in patients with severe acute respiratory distress syndrome: a prospective, observational study.

A J C Burrell, M Lubnow, T B Enger, V B Nanjayya, A Philipp, M V Malfertheiner, D Lunz, T Bein, V A Pellegrino, T Müller

Abstract readObservational Study
PubMed
In one paragraph

Observational study in Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. ARDS Clinical Practice Guideline 2021.Journal of intensive care · 2022
    Article
  11. Review
  12. Review
  13. Review
  14. Extracorporeal life support and systemic inflammation.Intensive care medicine experimental · 2019
    Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

A J C BurrellDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany. thomas.mueller@ukr.de.
M LubnowDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
T B EngerDepartment of Intensive Care Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
V B NanjayyaDepartment of Anaesthesia, Alfred Hospital, Melbourne, Australia.
A PhilippDepartment of Cardiothoracic and Vascular Surgery, University Hospital Regensburg, Regensburg, Germany.
M V MalfertheinerDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
D LunzDepartment of Intensive Care Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
T BeinDepartment of Cardiothoracic and Vascular Surgery, University Hospital Regensburg, Regensburg, Germany.
V A PellegrinoDepartment of Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
T MüllerDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe immunoinflammatory response is central to the pathogenesis of acute respiratory distress syndrome (ARDS). However, little is known how this is affected by venovenous (VV) extracorporeal membrane oxygenation (ECMO). Our objective was to investigate the factors that influence the inflammatory response of patients with ARDS undergoing VV ECMO, and to analyse the impact of this response on hospital mortality. DESIGN AND

settingA prospective observational study of all consecutive patients with severe ARDS who had VV ECMO at a tertiary German ECMO centre from 2009 to 2015. Patients without complete datasets were excluded. Cytokines (interleukin [IL]6, IL8 and tissue necrosis factor [TNF]

resultsA total of 262 adult patients undergoing VV ECMO were analysed. Their median Sequential Organ Failure Assessment score was 12, PaO

conclusionCytokine levels, on average, fall rapidly after initiation of VV ECMO, which may be related to the reduction of invasiveness of mechanical ventilation. Higher cytokine levels are associated with extrapulmonary causes of ARDS, more aggressive mechanical ventilation before VV ECMO, and mortality.

Indexed as

Extracorporeal Membrane OxygenationAdultCytokinesGermanyHospital MortalityHumansProspective StudiesRespiration, ArtificialRespiratory Distress SyndromeRespiratory InsufficiencyTreatment OutcomeCytokines

Identifiers

PMID29084500

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.